ARCD_CLOPE
ID ARCD_CLOPE Reviewed; 478 AA.
AC Q46170;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Arginine/ornithine antiporter {ECO:0000250|UniProtKB:A2RNI5};
GN Name=arcD; OrderedLocusNames=CPE0170;
OS Clostridium perfringens (strain 13 / Type A).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=195102;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=13 / Type A;
RX PubMed=9053381; DOI=10.1111/j.1574-6968.1997.tb10186.x;
RA Ohtani K., Bando M., Swe T., Banu S., Oe M., Hayashi H., Shimizu T.;
RT "Collagenase gene (colA) is located in the 3'-flanking region of the
RT perfringolysin O (pfoA) locus in Clostridium perfringens.";
RL FEMS Microbiol. Lett. 146:155-159(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC -!- FUNCTION: Catalyzes electroneutral exchange between L-arginine and L-
CC ornithine. {ECO:0000250|UniProtKB:A2RNI5}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-
CC ornithine(out); Xref=Rhea:RHEA:34991, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000250|UniProtKB:A2RNI5};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC family. {ECO:0000305}.
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DR EMBL; X97768; CAA66366.1; -; Genomic_DNA.
DR EMBL; BA000016; BAB79876.1; -; Genomic_DNA.
DR RefSeq; WP_011009652.1; NC_003366.1.
DR AlphaFoldDB; Q46170; -.
DR SMR; Q46170; -.
DR STRING; 195102.gene:10489414; -.
DR EnsemblBacteria; BAB79876; BAB79876; BAB79876.
DR GeneID; 29572715; -.
DR KEGG; cpe:CPE0170; -.
DR HOGENOM; CLU_007946_1_2_9; -.
DR OMA; FNSDNRV; -.
DR Proteomes; UP000000818; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0043858; F:arginine:ornithine antiporter activity; IEA:InterPro.
DR GO; GO:0006527; P:arginine catabolic process; IEA:InterPro.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:InterPro.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004754; Amino_acid_antiprt.
DR InterPro; IPR022461; Arg/Orn_antiprt_ArcD.
DR Pfam; PF13520; AA_permease_2; 1.
DR TIGRFAMs; TIGR00905; 2A0302; 1.
DR TIGRFAMs; TIGR03810; arg_ornith_anti; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Antiport; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..478
FT /note="Arginine/ornithine antiporter"
FT /id="PRO_0000054237"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 83
FT /note="Missing (in Ref. 1; CAA66366)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="Missing (in Ref. 1; CAA66366)"
FT /evidence="ECO:0000305"
FT CONFLICT 352
FT /note="A -> V (in Ref. 1; CAA66366)"
FT /evidence="ECO:0000305"
FT CONFLICT 417
FT /note="G -> E (in Ref. 1; CAA66366)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 478 AA; 51088 MW; A7BA24F7B53A344B CRC64;
MAEQHNEPKK LGFAQLAALI VGSMIGGGAF NLPSDMARGA GTGAVIIGWI ITGIGMIALA
FVYQSLANRK PELTGGVYSY AKAGFGEYIG FNSAWGYWLS AWIGNVSYSV LLFGAVGYFL
PMFGAGNNVA SIIGASVLLW AFTLLILNGV SGAALINLIT TIAKLVPIFL FIVISLFMFN
FDKFTFQFWG TSDLGGIVTQ VKSTMLVTLW CFIGIEGAVV VSGRAKKQSD VGKATVLGLI
GTLIIYMLIT LMALGVMDRV KLSGLENPSM AYVLEFAVGK WGAVLINLGL IISLFGSLLG
WALLAAEIPY VAAKDGVLPK VFAKLNKKGT PSGSLIITNL LVQAFLILTL VASSTYQALY
SVASTAILVP YLLSAMYGFK LALTGETYDK NPTGRTRDKI FGGIATVYAI WLCYAAGLKY
LLLCFILYAV GIIFFYIGKK QNNKDAEVFV GKEKILAIIV LVIAIIAIVM LFNGTITI
