ARCD_HALSA
ID ARCD_HALSA Reviewed; 485 AA.
AC Q9HHN1;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Arginine/ornithine antiporter ArcD {ECO:0000250|UniProtKB:B0R9X2};
GN Name=arcD; OrderedLocusNames=VNG_6313G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OG Plasmid pNRC200.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Uptake of arginine from the medium in exchange for ornithine.
CC {ECO:0000250|UniProtKB:B0R9X2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-
CC ornithine(out); Xref=Rhea:RHEA:34991, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000250|UniProtKB:B0R9X2};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:34992;
CC Evidence={ECO:0000250|UniProtKB:B0R9X2};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B0R9X2};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004438; AAG20945.1; -; Genomic_DNA.
DR RefSeq; WP_010904158.1; NZ_BK010831.1.
DR AlphaFoldDB; Q9HHN1; -.
DR EnsemblBacteria; AAG20945; AAG20945; VNG_6313G.
DR GeneID; 5954935; -.
DR GeneID; 62888213; -.
DR KEGG; hal:VNG_6313G; -.
DR PATRIC; fig|64091.14.peg.2291; -.
DR HOGENOM; CLU_033405_1_0_2; -.
DR InParanoid; Q9HHN1; -.
DR OMA; AFFNLVC; -.
DR OrthoDB; 35368at2157; -.
DR PhylomeDB; Q9HHN1; -.
DR Proteomes; UP000000554; Plasmid pNRC200.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Antiport; Cell membrane; Membrane; Plasmid;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..485
FT /note="Arginine/ornithine antiporter ArcD"
FT /id="PRO_0000411688"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 485 AA; 50523 MW; 6FAC7AE066601350 CRC64;
MVEFEPRSYE DFDPEKRPSF GQALLPIAGM ITFLAVGIVL LGLDAQMPLL WGIAFTGVIA
RYGWGYTWDE LFDGISNSIV MGLGAIFILF IIYMLIASWV DAGTIPFIMY WGLEFLTPAV
FVPLAALLSF VVATAIGSSW TTAGSLGIAL VGIGSGLGIP APLTAGAILS GVYMGDKQSP
LSDTTLLASG VSDVDLWDHV RGMFPNTIIV GVISLALYAV LGLMAETGGT GGTGAEVAQI
QGGLAGTYTL SVLVLLPLVI TFGLAIKGYP ALPSLGAGVF SAAGVSILIQ GRGFAEAWQI
IYSGTGPKTG VDLVNNLLST GGLEGSIWVI TIVFGALSIG GILEATGVLS VIAHNTAKAV
DSVGGATLVT ALGPLVINAL TADQYMSIVI PGMTFRDLND EYDLDGTSLS RTLEETGTVS
EPMIPWNSGG VFMASALGVP VLSYLPYYFV GILSPILVVI MGFTGWKMYM KDPEESPEES
ADTAA
