ID   ARCD_LATSK              Reviewed;         475 AA.
AC   O53092;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Arginine/ornithine antiporter {ECO:0000250|UniProtKB:A2RNI5};
GN   Name=arcD;
OS   Latilactobacillus sakei (Lactobacillus sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=1599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9696763; DOI=10.1128/jb.180.16.4154-4159.1998;
RA   Zuniga M., Champomier-Verges M.-C., Zagorec M., Perez-Martinez G.;
RT   "Structural and functional analysis of the gene cluster encoding the
RT   enzymes of the arginine deiminase pathway of Lactobacillus sakei.";
RL   J. Bacteriol. 180:4154-4159(1998).
CC   -!- FUNCTION: Catalyzes electroneutral exchange between L-arginine and L-
CC       ornithine. {ECO:0000250|UniProtKB:A2RNI5}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-
CC         ornithine(out); Xref=Rhea:RHEA:34991, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:46911; Evidence={ECO:0000250|UniProtKB:A2RNI5};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ001330; CAA04686.1; -; Genomic_DNA.
DR   PIR; T46745; T46745.
DR   AlphaFoldDB; O53092; -.
DR   SMR; O53092; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0043858; F:arginine:ornithine antiporter activity; IEA:InterPro.
DR   GO; GO:0006527; P:arginine catabolic process; IEA:InterPro.
DR   GO; GO:1903826; P:L-arginine transmembrane transport; IEA:InterPro.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   InterPro; IPR022461; Arg/Orn_antiprt_ArcD.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
DR   TIGRFAMs; TIGR03810; arg_ornith_anti; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Antiport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..475
FT                   /note="Arginine/ornithine antiporter"
FT                   /id="PRO_0000054238"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   475 AA;  51881 MW;  8E91A01F6A2203CC CRC64;
     MTEEKPAKKI GLLALIALVI SSSIGSGVFG LTSDLASASA PGPVLIAWVI VGFGILMLAL
     SLNNLLMKEP ELEGIFSYAE KGFGPFAGFI SGWGYWLSAW LGNVTFATIL MSALGYFFPI
     FKSRQNLPSI LVASVLSWSL TYFVNRGVEG AAAINTLVTI CKLIPLFVFI IFGIVLFKGH
     LFTQAFWNNM SSSFVAGDVM SQIKNCMMVM MWVFVGIEGA SMLSARAEKK SDAGKATILG
     LVSLLAIYIL ASVLPYGYLT QDQLASIKQP AMLYIFEQMV GTWGGYFIGV GLIISILGAW
     LSWTMLPAET MLLMAKQNLL PAYFGRVNKK KAPTFALVVT AGLIQVFLFT LLFTTKAYNF
     AYSLCTASII VCYMLVAAYQ IKYSWAHLQE KGNRQQLLIG VLALLFEIAG ILMAGVSYLL
     LCFIAYIPGI YFYGRARKNN GHQHFLSKGE WLITTIIVIG AIIGIWLVVS GKIVI