ID   LACI_KLEPN              Reviewed;         354 AA.
AC   P06220;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Lactose operon repressor;
DE   Flags: Fragment;
GN   Name=lacI;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3897196; DOI=10.1128/jb.163.3.850-857.1985;
RA   Buvinger W.E., Riley M.;
RT   "Nucleotide sequence of Klebsiella pneumoniae lac genes.";
RL   J. Bacteriol. 163:850-857(1985).
CC   -!- FUNCTION: Repressor of the lactose operon. Binds lactose as an inducer.
CC   -!- SUBUNIT: Homotetramer.
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DR   EMBL; M11441; AAA25081.2; -; Genomic_DNA.
DR   PIR; B24925; B24925.
DR   AlphaFoldDB; P06220; -.
DR   SMR; P06220; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..>354
FT                   /note="Lactose operon repressor"
FT                   /id="PRO_0000107964"
FT   DOMAIN          6..60
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        8..27
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   NON_TER         354
SQ   SEQUENCE   354 AA;  38676 MW;  239136402AA4462C CRC64;
     MPRRTATLED VARRGRVPAD GLRRVLNRPE VVSARTREQV IRAMQALHYV PNRSAQLLAG
     KAAPSIGLIT ASVTLHAPSQ IAAAIKSHAS LHQLEVAIAM PAQADFVALQ ARLDELRAQH
     IRGVIVSLPL ESATAERLVQ DNPDMACLFL DVSPEADVCC VRFDHRDGCG ACVRHLWEMG
     HREFGLLAGP ESSVSARLRL ASWREALHSL NIARSTTVFG DWSAASGWQK TFELLHLQPR
     ISAIVVANDQ MALGVLSALA QLNRSGSQAV SVTGYDDTAD SLYFQPPLTT VAQDFDLLGK
     RAVERLIALM AAPQLRIREL LPTRLIVRQS AWPVAAAEDR QQTLAQLKAL VEKL