ID   LACK_RHIRD              Reviewed;         363 AA.
AC   Q01937;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Lactose transport ATP-binding protein LacK;
GN   Name=lacK;
OS   Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium
OS   radiobacter).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AR50;
RX   PubMed=1630315; DOI=10.1111/j.1365-2958.1992.tb01348.x;
RA   Williams S.G., Greenwood J.A., Jones C.W.;
RT   "Molecular analysis of the lac operon encoding the binding-protein-
RT   dependent lactose transport system and beta-galactosidase in Agrobacterium
RT   radiobacter.";
RL   Mol. Microbiol. 6:1755-1768(1992).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       lactose. Probably responsible for energy coupling to the transport
CC       system.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; X66596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S34734; S34734.
DR   AlphaFoldDB; Q01937; -.
DR   SMR; Q01937; -.
DR   TCDB; 3.A.1.1.4; the atp-binding cassette (abc) superfamily.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   CDD; cd03301; ABC_MalK_N; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015855; ABC_transpr_MalK-like.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR040582; OB_MalK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF17912; OB_MalK; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Sugar transport; Transport.
FT   CHAIN           1..363
FT                   /note="Lactose transport ATP-binding protein LacK"
FT                   /id="PRO_0000092396"
FT   DOMAIN          4..234
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   363 AA;  39324 MW;  1B1F8CC29453B8B2 CRC64;
     MAEVRLTDIR KSYGSLEVIK GVNLEVSSGE FVVFVGPSGC GKSTLLRMIA GLEDISSGEL
     TIGGTVMNDV DPSKRGIAMV FQTYALYPHM TVRENMGFAL RFAGMAKDEI ERRVNAAAKI
     LELDALMDRK PKALSGGQRQ RVAIGRAIVR QPDVFLFDEP LSNLDAELRV HMRVEIARLH
     KELNATIVYV THDQVEAMTL ADKIVVMRGG IVEQVGAPLA LYDDPDNMFV AGFIGSPRMN
     FLPAVVIGQA EGGQVTVALK ARPDTQLTVA CATPPQGGDA VTVGVRPEHF LPAGSGDTQL
     TAHVDVVEHL GNTSYVYAHT VPGEQIIIEQ EERRHGGRYG DEIAVGISAK TSFLFDASGR
     RIR