ID   LACP_STAXY              Reviewed;         462 AA.
AC   O33814;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Lactose permease;
DE   AltName: Full=Lactose transport protein;
DE   AltName: Full=Lactose-proton symporter;
GN   Name=lacP;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=9573174; DOI=10.1128/jb.180.9.2273-2279.1998;
RA   Bassias J., Brueckner R.;
RT   "Regulation of lactose utilization genes in Staphylococcus xylosus.";
RL   J. Bacteriol. 180:2273-2279(1998).
CC   -!- FUNCTION: Responsible for transport of beta-galactosides into the cell,
CC       with the concomitant uptake of protons (symport system), and also for
CC       transport of homologous and heterologous exchange of beta-galactosides.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC       family. {ECO:0000305}.
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DR   EMBL; Y14599; CAA74936.1; -; Genomic_DNA.
DR   RefSeq; WP_047171675.1; NZ_QXUG01000013.1.
DR   AlphaFoldDB; O33814; -.
DR   SMR; O33814; -.
DR   STRING; 1288.SXYLSMQ121_0083; -.
DR   KEGG; sxo:SXYL_00083; -.
DR   eggNOG; COG2211; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR039672; MFS_2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001927; Na/Gal_symport.
DR   InterPro; IPR018043; Na/Gal_symport_CS.
DR   PANTHER; PTHR11328; PTHR11328; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00792; gph; 1.
DR   PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..462
FT                   /note="Lactose permease"
FT                   /id="PRO_0000170756"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  51667 MW;  A1B7FA6F07BA5D48 CRC64;
     MNRHLTGKQK FAFGFGAIGK DAIFNIVSVF LMFYITDIVG LSPAFVGVML FVARIWDAIN
     DPIMGMIVDN TRNNFGKFKT WLVIGTLINA VVTVLLFTNF DLSQTAMYIY ISIIYISWGM
     TYTMMDIPYW SWLPNLTHDP REREELSVIP RFFASLAAFT VGTFGLFFIH KLGDIFGGGS
     DSTGIFVFAI ICSLIFIFTI GVTVFKVPED QEMEKLIGIK VKFKDIGRIL FKNKELLAIM
     GVLLTFNLCL QTLNGSIIYY FKYVVNAEHL FAIFNSMILC EMVGLLLLPR FIKWVGRTAA
     FNTSIICIIS GLLIILISGY IAPQSMTLII IGAGILRIGS GFMVGITTVS LADVIDYGEV
     KFGQRNESII TSTNTFLTKT SQAVAALIVG LGLSILGYTP NEAQSVVTIN GLRIMILVSP
     LVFICLAAFL YHKAFNLKGD FLTDIEKTLQ YKRQREFRER IK