ID   LACR_LACHE              Reviewed;         335 AA.
AC   Q7WTB0;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=HTH-type transcriptional regulator LacR;
DE   AltName: Full=Lactose operon repressor;
GN   Name=lacR;
OS   Lactobacillus helveticus (Lactobacillus suntoryeus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TRANSCRIPTIONAL REGULATION.
RC   STRAIN=ATCC 15009 / DSM 20075 / BCRC 12936 / JCM 1120 / NBRC 15019 / NCIMB
RC   11971 / NRRL B-4526 / Lh12;
RX   PubMed=12788721; DOI=10.1128/aem.69.6.3238-3243.2003;
RA   Fortina M.G., Ricci G., Mora D., Guglielmetti S., Manachini P.L.;
RT   "Unusual organization for lactose and galactose gene clusters in
RT   Lactobacillus helveticus.";
RL   Appl. Environ. Microbiol. 69:3238-3243(2003).
CC   -!- FUNCTION: Negatively regulates the transcription of the lactose
CC       utilization genes lacL and lacM.
CC   -!- PATHWAY: Carbohydrate metabolism; lactose degradation [regulation].
CC   -!- INDUCTION: By glucose. {ECO:0000269|PubMed:12788721}.
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DR   EMBL; AJ512880; CAD55503.1; -; Genomic_DNA.
DR   RefSeq; WP_003627055.1; NZ_SCLV01000187.1.
DR   AlphaFoldDB; Q7WTB0; -.
DR   SMR; Q7WTB0; -.
DR   STRING; 326425.lhe_1441; -.
DR   GeneID; 66452192; -.
DR   eggNOG; COG1609; Bacteria.
DR   UniPathway; UPA00542; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005990; P:lactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..335
FT                   /note="HTH-type transcriptional regulator LacR"
FT                   /id="PRO_0000107965"
FT   DOMAIN          1..58
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   335 AA;  37755 MW;  B1C8035F99A5B74E CRC64;
     MRTIKEIALE SGYSPATVSR LLNNDPNLSI TADTKNKILE IANKLGYWED HQEKKIKPTI
     ALLYRVNHNE QLQDEYFTSL KQALVSTVER DALKMKTFYD IEDLIKNASL FQGFIGVGAE
     PIENAQLVKL HKVLPNGVFV DTNPAPELFD SIRPNLPFTV KNAIDLFIKN GINKIGFIGG
     VGPKHDHIQE NDLRSITFVE YMKTRGMDTK WTCVEGPVSV ENGYKLGKMV LAKYKNDLPE
     AFLIASDTLA VGVLQAFNEE NVNVPKDTKI LSINNSNVVK YVSPPLSSFN INQQEMIDMA
     LDTLTHLIIR PDRPNIDIRM NTNLVVRKSF VPQEK