ID   LACR_STAA8              Reviewed;         251 AA.
AC   P0A0Q0; P16644; Q2G2R1;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Lactose phosphotransferase system repressor;
GN   Name=lacR; OrderedLocusNames=SAOUHSC_02456;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2163387; DOI=10.1128/jb.172.7.3804-3812.1990;
RA   Oskouian B., Stewart G.C.;
RT   "Repression and catabolite repression of the lactose operon of
RT   Staphylococcus aureus.";
RL   J. Bacteriol. 172:3804-3812(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Repressor of the lactose catabolism operon. Galactose-6-
CC       phosphate is the inducer.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD31476.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M32103; AAA67854.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD31476.1; ALT_INIT; Genomic_DNA.
DR   PIR; A44506; A44506.
DR   RefSeq; YP_500923.1; NC_007795.1.
DR   AlphaFoldDB; P0A0Q0; -.
DR   SMR; P0A0Q0; -.
DR   STRING; 1280.SAXN108_2449; -.
DR   EnsemblBacteria; ABD31476; ABD31476; SAOUHSC_02456.
DR   GeneID; 3919019; -.
DR   KEGG; sao:SAOUHSC_02456; -.
DR   PATRIC; fig|93061.5.peg.2215; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_1_0_9; -.
DR   PRO; PR:P0A0Q0; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005988; P:lactose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:CACAO.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Lactose metabolism; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Lactose phosphotransferase system repressor"
FT                   /id="PRO_0000050262"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   251 AA;  28549 MW;  9997A1DA3211AC4E CRC64;
     MNKHERLDEI AKLVNKKGTI RTNEIVEGLN VSDMTVRRDL IELENKGILT KIHGGARSNS
     TFQYKEISHK EKHTRQIAEK RFIAKKAASL IEDGDTLFFG PGTTVELLAE EVNHHTLTII
     TNCLPVYKIL LEKQTAHFRV YLIGGEMRHI TEAFVGEMAN AMLEKLRFSK MFFSSNAVNK
     GAVMTSTLDE AYTQQLALSN SIEKYLLIDH TKVGKEDFTS FCQLNELTAV VMDYEDEEKV
     ETIKTYIEVV D