ID   LACR_STAAR              Reviewed;         251 AA.
AC   Q6GEN3;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Lactose phosphotransferase system repressor;
GN   Name=lacR; OrderedLocusNames=SAR2287;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Repressor of the lactose catabolism operon. Galactose-6-
CC       phosphate is the inducer (By similarity). {ECO:0000250}.
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DR   EMBL; BX571856; CAG41265.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6GEN3; -.
DR   SMR; Q6GEN3; -.
DR   KEGG; sar:SAR2287; -.
DR   HOGENOM; CLU_060699_1_0_9; -.
DR   OMA; MFQTVPT; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005988; P:lactose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Lactose metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Lactose phosphotransferase system repressor"
FT                   /id="PRO_0000050260"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   251 AA;  28577 MW;  FD7D6D372CDE982E CRC64;
     MNKHERLDEI AKLVNKKGTI RTNEIVEGLN VSDMTVRRDL IELENKGILT KIHGGARSNS
     TFQYKEISHK EKHTRQIAEK RFIARKAASL IEDGDTLFFG PGTTVELLAE EVNHHTLTII
     TNCLPVYKIL LEKQTAHFRV YLIGGEMRHI TEAFVGEMAN AMLEKLRFSK MFFSSNAVNK
     GAVMTSTLDE AYTQQLALSN SIEKYLLIDH TKVGKEDFTS FCQLNELTAV VMDYEDEEKV
     ETIKTYIEVV D