ID   LACR_STAEQ              Reviewed;         251 AA.
AC   Q5HM34;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Lactose phosphotransferase system repressor;
GN   Name=lacR; OrderedLocusNames=SERP1796;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Repressor of the lactose catabolism operon. Galactose-6-
CC       phosphate is the inducer (By similarity). {ECO:0000250}.
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DR   EMBL; CP000029; AAW55181.1; -; Genomic_DNA.
DR   RefSeq; WP_001829761.1; NC_002976.3.
DR   AlphaFoldDB; Q5HM34; -.
DR   SMR; Q5HM34; -.
DR   STRING; 176279.SERP1796; -.
DR   EnsemblBacteria; AAW55181; AAW55181; SERP1796.
DR   GeneID; 50018108; -.
DR   KEGG; ser:SERP1796; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_1_0_9; -.
DR   OMA; MFQTVPT; -.
DR   OrthoDB; 1629121at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005988; P:lactose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Lactose metabolism; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Lactose phosphotransferase system repressor"
FT                   /id="PRO_0000050265"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   251 AA;  28658 MW;  5A5187911915C85C CRC64;
     MNKYDRLDEI TKLVNKRGSV RTNEIVEDLN VSDMTVRRDL AELEEKGVLT KIHGGARSNS
     AFQYKEMSHQ EKHTRFIEEK RFIAKNAVDL IEDGDTIFLG PGTTVQKLAE EINHYSLTII
     TNCLPVFNIL IKKQTLHFRV YLLGGEMRDL TEAFVGEMTN QLLSQLRFSK MFFSSNGVKD
     GLAMTSSIEE AYTQQIALSH SLEKYLLIDS SKIGKDDFSS FCELRELNAV LTDNNDLEKK
     EKIESYVEVI S