ID   LACR_STAES              Reviewed;         251 AA.
AC   Q8CRJ1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Lactose phosphotransferase system repressor;
GN   Name=lacR; OrderedLocusNames=SE_1788;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Repressor of the lactose catabolism operon. Galactose-6-
CC       phosphate is the inducer (By similarity). {ECO:0000250}.
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DR   EMBL; AE015929; AAO05429.1; -; Genomic_DNA.
DR   RefSeq; NP_765343.1; NC_004461.1.
DR   RefSeq; WP_001829761.1; NZ_WBME01000007.1.
DR   AlphaFoldDB; Q8CRJ1; -.
DR   SMR; Q8CRJ1; -.
DR   STRING; 176280.SE_1788; -.
DR   EnsemblBacteria; AAO05429; AAO05429; SE_1788.
DR   GeneID; 50018108; -.
DR   KEGG; sep:SE_1788; -.
DR   PATRIC; fig|176280.10.peg.1745; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_1_0_9; -.
DR   OMA; MFQTVPT; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005988; P:lactose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Lactose metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Lactose phosphotransferase system repressor"
FT                   /id="PRO_0000050264"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   251 AA;  28658 MW;  5A5187911915C85C CRC64;
     MNKYDRLDEI TKLVNKRGSV RTNEIVEDLN VSDMTVRRDL AELEEKGVLT KIHGGARSNS
     AFQYKEMSHQ EKHTRFIEEK RFIAKNAVDL IEDGDTIFLG PGTTVQKLAE EINHYSLTII
     TNCLPVFNIL IKKQTLHFRV YLLGGEMRDL TEAFVGEMTN QLLSQLRFSK MFFSSNGVKD
     GLAMTSSIEE AYTQQIALSH SLEKYLLIDS SKIGKDDFSS FCELRELNAV LTDNNDLEKK
     EKIESYVEVI S