ID   LACR_STAXY              Reviewed;         279 AA.
AC   O33813;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Lactose operon transcription activator;
GN   Name=lacR;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=9573174; DOI=10.1128/jb.180.9.2273-2279.1998;
RA   Bassias J., Brueckner R.;
RT   "Regulation of lactose utilization genes in Staphylococcus xylosus.";
RL   J. Bacteriol. 180:2273-2279(1998).
CC   -!- FUNCTION: Transcriptional regulator of the lacPH genes for lactose
CC       utilization.
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DR   EMBL; Y14599; CAA74935.1; -; Genomic_DNA.
DR   RefSeq; WP_042361763.1; NZ_QXUG01000013.1.
DR   AlphaFoldDB; O33813; -.
DR   SMR; O33813; -.
DR   STRING; 1288.SXYLSMQ121_0082; -.
DR   GeneID; 45495725; -.
DR   KEGG; sxl:SXYLSMQ121_0082; -.
DR   KEGG; sxo:SXYL_00082; -.
DR   eggNOG; COG2207; Bacteria.
DR   OrthoDB; 1785082at2; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..279
FT                   /note="Lactose operon transcription activator"
FT                   /id="PRO_0000194528"
FT   DOMAIN          174..272
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        191..212
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        239..262
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   279 AA;  32335 MW;  304CDF65A7B14D34 CRC64;
     MQVLWKKFQK KLIDANLAEC GIEIGVPNVG YNYTVFQKSV LHIVTQGEGT FSYAGETYHL
     TAGDIFLLER GMEVEYKPSF SNPWTYYWVG MNGKQILNYL SRCSIVDSHV ILGQDTTDIK
     NIIQLICKLS QSIESNNSND ILIMQYLYQL VYTLQEKFPK IFSVQVDIVN EDIQHAVDFI
     NTNYQKHITV EDVAKSVNIT RSHLYKLFKK NLGCSPKEYL TYIRMYHASQ LLIHTSTLIS
     DISRQVGYKD PLLFSKNFTK HFEISASEYR HHFSINNKQ