ID   LACR_STRMU              Reviewed;         251 AA.
AC   P26422;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Lactose phosphotransferase system repressor;
GN   Name=lacR; OrderedLocusNames=SMU_1498;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1400164; DOI=10.1128/jb.174.19.6159-6170.1992;
RA   Rosey E.L., Stewart G.C.;
RT   "Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and
RT   lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and
RT   sugar-specific phosphotransferase system components of the lactose operon
RT   of Streptococcus mutans.";
RL   J. Bacteriol. 174:6159-6170(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Repressor of the lactose catabolism operon. Galactose-6-
CC       phosphate is the inducer.
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DR   EMBL; M80797; AAA26903.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN59151.1; -; Genomic_DNA.
DR   PIR; B43258; B43258.
DR   RefSeq; NP_721845.1; NC_004350.2.
DR   RefSeq; WP_002262461.1; NC_004350.2.
DR   AlphaFoldDB; P26422; -.
DR   SMR; P26422; -.
DR   STRING; 210007.SMU_1498; -.
DR   PRIDE; P26422; -.
DR   EnsemblBacteria; AAN59151; AAN59151; SMU_1498.
DR   KEGG; smu:SMU_1498; -.
DR   PATRIC; fig|210007.7.peg.1333; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_1_0_9; -.
DR   OMA; MFQTVPT; -.
DR   PhylomeDB; P26422; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005988; P:lactose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Lactose metabolism; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Lactose phosphotransferase system repressor"
FT                   /id="PRO_0000050266"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   CONFLICT        2
FT                   /note="R -> K (in Ref. 1; AAA26903)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206
FT                   /note="L -> F (in Ref. 1; AAA26903)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   251 AA;  28704 MW;  58BD08EC88E52948 CRC64;
     MRKEERLEEI TKLINKRGTI RVTEVVERLK VSDMTVRRDL TELEGLGVLT RIHGGARSNN
     IFQYKEMSHE EKHSRQIEEK HYIAQKAAEL VEEGDTIFLG PGTTVELLAE EINKTTLQVI
     TNCLPVFQIL SQKQSETFRV HLLGGEMRSI TQSFIGEITN IVLEKMHFSK MFFSGNGVKG
     NEVMTSSFQE AYTQKMALGR AIEKYLLIDS SKIGKEDFTS FYQLSQLTAL ITDCQDDDKL
     QKLSKYTEII N