ID   LAC_PIG                 Reviewed;         105 AA.
AC   P01846;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Ig lambda chain C region;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=409425; DOI=10.1021/bi00636a006;
RA   Novotny J., Franek F., Margolies M.N., Haber E.;
RT   "Amino acid sequence of normal (microheterogeneous) porcine immunoglobulin
RT   lambda chains.";
RL   Biochemistry 16:3765-3772(1977).
CC   -!- MISCELLANEOUS: This chain was obtained from a mixture of normal
CC       immunoglobulins.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A02129; L1PG.
DR   AlphaFoldDB; P01846; -.
DR   SMR; P01846; -.
DR   PaxDb; P01846; -.
DR   PeptideAtlas; P01846; -.
DR   PRIDE; P01846; -.
DR   Ensembl; ENSSSCT00005066648; ENSSSCP00005041328; ENSSSCG00005041603.
DR   Ensembl; ENSSSCT00070017836; ENSSSCP00070014795; ENSSSCG00070009195.
DR   HOGENOM; CLU_077975_6_3_1; -.
DR   InParanoid; P01846; -.
DR   OMA; MVWTPLL; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unassembled WGS sequence.
DR   Genevisible; P01846; SS.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Immunoglobulin domain;
KW   Reference proteome.
FT   CHAIN           <1..105
FT                   /note="Ig lambda chain C region"
FT                   /id="PRO_0000153613"
FT   DOMAIN          2..100
FT                   /note="Ig-like"
FT   DISULFID        27..86
FT   DISULFID        104
FT                   /note="Interchain (with heavy chain)"
FT   NON_TER         1
SQ   SEQUENCE   105 AA;  11003 MW;  3817AAEBD747C396 CRC64;
     QPKAAPTVNL FPPSSEELGT NKATLVCLIS DFYPGAVTVT WKAGGTTVTQ GVETTKPSKQ
     SNNKYAASSY LALSASDWKS SSGFTCQVTH EGTIVEKTVT PSECA