ID   LADH_META3              Reviewed;         465 AA.
AC   A6UVT6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Lactaldehyde dehydrogenase;
DE            EC=1.2.1.22;
GN   OrderedLocusNames=Maeo_1030;
OS   Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS   Nankai-3).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=419665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in F420 biosynthesis through the oxidation of
CC       lactaldehyde to lactate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:14277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:18041, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.22;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000743; ABR56608.1; -; Genomic_DNA.
DR   RefSeq; WP_011973740.1; NC_009635.1.
DR   AlphaFoldDB; A6UVT6; -.
DR   SMR; A6UVT6; -.
DR   STRING; 419665.Maeo_1030; -.
DR   EnsemblBacteria; ABR56608; ABR56608; Maeo_1030.
DR   GeneID; 5327289; -.
DR   KEGG; mae:Maeo_1030; -.
DR   eggNOG; arCOG01252; Archaea.
DR   HOGENOM; CLU_005391_1_0_2; -.
DR   OMA; WHKLIEQ; -.
DR   OrthoDB; 42527at2157; -.
DR   UniPathway; UPA00071; -.
DR   Proteomes; UP000001106; Chromosome.
DR   GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..465
FT                   /note="Lactaldehyde dehydrogenase"
FT                   /id="PRO_0000342589"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        274
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         220..225
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   465 AA;  51327 MW;  921D851D658893FC CRC64;
     MFINGEWINR KDIEVKNPYN NEIIGYIPSL SRNETKEAIK IAEEHKSTMK NLSPTIRYNI
     LMKIASELSK NKRELAKLIT IDVGKPIKQS IIEVDRTITT FKFSAFYSRE LRGETIPFDD
     GMVITKREPV GLVGAITPFN FPLNLFAHKI APAIAMGNSI VAHPSSKAPM ITIELTKIIE
     KVLKSKKIPL GVFNLLTGEG HIVGDEIVKN NKINKLSFTG SVEVGESITK KAGFKKITLE
     LGGNNPMIIL KDANINKAVE SCMSGKFLNS GQVCISVGRV LIEQEVADEF INKIVEKVKK
     LKIGNPLDED TNISSLISLD SAERVEKLIN KSIGQGGKLI CGGKRENSII YPTILEITAD
     NILANIEIFA PVLPIIRVND MNEALNQANN SNYGLHSGVF TQDINKALYF ADNLEYGGVL
     INNSPTFRID NMPFGGIKHS GLGREGIKYA IDEMSEIKTI IVNTK