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LADH_METM5
ID   LADH_METM5              Reviewed;         465 AA.
AC   A4FW36;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Lactaldehyde dehydrogenase;
DE            EC=1.2.1.22;
GN   OrderedLocusNames=MmarC5_0090;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in F420 biosynthesis through the oxidation of
CC       lactaldehyde to lactate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:14277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:18041, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.22;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000609; ABO34407.1; -; Genomic_DNA.
DR   RefSeq; WP_011867868.1; NC_009135.1.
DR   AlphaFoldDB; A4FW36; -.
DR   SMR; A4FW36; -.
DR   STRING; 402880.MmarC5_0090; -.
DR   EnsemblBacteria; ABO34407; ABO34407; MmarC5_0090.
DR   GeneID; 4928313; -.
DR   KEGG; mmq:MmarC5_0090; -.
DR   eggNOG; arCOG01252; Archaea.
DR   HOGENOM; CLU_005391_1_0_2; -.
DR   OMA; WHKLIEQ; -.
DR   OrthoDB; 42527at2157; -.
DR   UniPathway; UPA00071; -.
DR   Proteomes; UP000000253; Chromosome.
DR   GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..465
FT                   /note="Lactaldehyde dehydrogenase"
FT                   /id="PRO_0000342590"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        274
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         220..225
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   465 AA;  50803 MW;  37DC771138E8154A CRC64;
     MFIDGKWILR EDIDVFDPYT LENIEKITAL DREETKSAIE VAEKNKEIMK NLSPSKRYSI
     LMKIAEQISL KKDLFAKTIS IDVGKPIKQS KIEVDRTLTA LKLSAFYAKE LRGETINSEN
     GLIFTKKEPL GVVGAITPFN FPLNLITHKI GPAIATGNSV VLHPSSKAPI VAIYLTKIIE
     HVLKQMDVPR GIFNLATGNG DIVGDEISKN DNINMVSFTG SVEVGESISK NAKMKKVALE
     LGGNNPMIVL KDSDIKLAAK SAVKSKFLNA GQVCISVGQV LVEEEVLETF TKHVIEETKK
     LILGNPLDTK TDIGPLISPE SALRIENLIK KSVNEGGEVL IGGNRQNSLI SPAVINIDEN
     NILSKIETFG PVLPILKVKD SEEAVSIANN SKYGLQAGVF TNDINKAMKI ADSLEYGGIM
     INSSPTFRKD NMPFGGVKKS GLGREGIKYT VEEMCETKTI VIHNI
 
 
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