ID   LADH_METM7              Reviewed;         465 AA.
AC   A6VH72;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Lactaldehyde dehydrogenase;
DE            EC=1.2.1.22;
GN   OrderedLocusNames=MmarC7_0731;
OS   Methanococcus maripaludis (strain C7 / ATCC BAA-1331).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=426368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C7 / ATCC BAA-1331;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus maripaludis C7.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in F420 biosynthesis through the oxidation of
CC       lactaldehyde to lactate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:14277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:18041, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.22;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000745; ABR65798.1; -; Genomic_DNA.
DR   RefSeq; WP_011977118.1; NC_009637.1.
DR   AlphaFoldDB; A6VH72; -.
DR   SMR; A6VH72; -.
DR   STRING; 426368.MmarC7_0731; -.
DR   EnsemblBacteria; ABR65798; ABR65798; MmarC7_0731.
DR   GeneID; 5327882; -.
DR   KEGG; mmz:MmarC7_0731; -.
DR   eggNOG; arCOG01252; Archaea.
DR   HOGENOM; CLU_005391_1_0_2; -.
DR   OMA; GMKYVTM; -.
DR   OrthoDB; 42527at2157; -.
DR   UniPathway; UPA00071; -.
DR   GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..465
FT                   /note="Lactaldehyde dehydrogenase"
FT                   /id="PRO_0000342591"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        274
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         220..225
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   465 AA;  51010 MW;  6E7A60209265F421 CRC64;
     MFIDGKWIIR DDIDVFDPYT LKNIEKITAL DREETKNAIE ITEKNKEVMK NLSPSKRYSI
     LMKIAEQISL KKDLFAKTIS IDVGKPIKQS KIEVDRTLTA FRLSAFYAKE LRGETINSEN
     GLIFTKKEPL GVVGAITPFN FPLNLITHKI GPAIATGNSV ILHPSSKAPI AAIYLTKIIE
     HVLKQMDIPR GVFNLATGNG DIVGDEISKN DKINMVSFTG SVEIGESISK NAKMKKVTLE
     LGGNNPMIVL KDSDIKLAAK SAVKSKFLNA GQVCISVGQV LVEEEVLETF TKYIIDETKN
     LVLGNPLDTK TDIGPLISPE SALRIENLIK ESVNEGGELL IGGNRQNSLI FPAVINIDED
     NLLSKIETFG PVLPILKVKN SEEAVSIANN SKYGLQAGVF TNDINKAMKI ADSLEYGGIM
     INSSPTFRKD NMPFGGVKKS GLGREGIKYT VEEMCETKTV VIHNI