ID   ARCH_BOVIN              Reviewed;         167 AA.
AC   Q2YDE7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein archease;
DE   AltName: Full=Protein ZBTB8OS;
GN   Name=ZBTB8OS; Synonyms=ARCH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the tRNA-splicing ligase complex required to
CC       facilitate the enzymatic turnover of catalytic subunit RTCB. Together
CC       with DDX1, acts by facilitating the guanylylation of RTCB, a key
CC       intermediate step in tRNA ligation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the tRNA-splicing ligase complex. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2YDE7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2YDE7-2; Sequence=VSP_024925;
CC   -!- SIMILARITY: Belongs to the archease family. {ECO:0000305}.
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DR   EMBL; BC110257; AAI10258.1; -; mRNA.
DR   EMBL; EE251558; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001069756.1; NM_001076288.2. [Q2YDE7-2]
DR   RefSeq; XP_005203056.1; XM_005202999.2. [Q2YDE7-1]
DR   AlphaFoldDB; Q2YDE7; -.
DR   SMR; Q2YDE7; -.
DR   STRING; 9913.ENSBTAP00000038735; -.
DR   PaxDb; Q2YDE7; -.
DR   Ensembl; ENSBTAT00000038929; ENSBTAP00000038735; ENSBTAG00000027159. [Q2YDE7-2]
DR   Ensembl; ENSBTAT00000038930; ENSBTAP00000038736; ENSBTAG00000027159. [Q2YDE7-1]
DR   GeneID; 613795; -.
DR   KEGG; bta:613795; -.
DR   CTD; 339487; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027159; -.
DR   eggNOG; KOG4528; Eukaryota.
DR   GeneTree; ENSGT00390000003245; -.
DR   HOGENOM; CLU_111362_0_0_1; -.
DR   InParanoid; Q2YDE7; -.
DR   OMA; WLSELLY; -.
DR   OrthoDB; 1360804at2759; -.
DR   TreeFam; TF105957; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000027159; Expressed in spermatocyte and 108 other tissues.
DR   ExpressionAtlas; Q2YDE7; baseline and differential.
DR   GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   Gene3D; 3.55.10.10; -; 1.
DR   InterPro; IPR002804; Archease.
DR   InterPro; IPR023572; Archease_dom.
DR   InterPro; IPR036820; Archease_dom_sf.
DR   PANTHER; PTHR12682; PTHR12682; 1.
DR   Pfam; PF01951; Archease; 1.
DR   SUPFAM; SSF69819; SSF69819; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Calcium; Metal-binding;
KW   Reference proteome; tRNA processing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IWT0"
FT   CHAIN           2..167
FT                   /note="Protein archease"
FT                   /id="PRO_0000285949"
FT   BINDING         39
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         166
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         167
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IWT0"
FT   VAR_SEQ         140..167
FT                   /note="GTEVKAITYSAMQVYNEEKPEVFVIIDI -> MPAAAAAASRFSRVRLCVTP
FT                   YTAAHQAPPSLGFSRELKSKQ (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_024925"
SQ   SEQUENCE   167 AA;  19432 MW;  124DF476591C13E1 CRC64;
     MALEGEDVRD YNLTEEQKAI KAKYPPVSRK YEYLDHTADV QLHAWGDTLE EAFEQCAMAM
     FGYMTDTGTV EPLQTIEVET QGDDLQSLLF HFLDEWLYKF SADEFFIPRE VKVLNIDQRN
     FKIRSIGWGE EFSLSKHPQG TEVKAITYSA MQVYNEEKPE VFVIIDI