ID   LADH_METVS              Reviewed;         465 AA.
AC   A6UQD0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Lactaldehyde dehydrogenase;
DE            EC=1.2.1.22;
GN   OrderedLocusNames=Mevan_0796;
OS   Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS   / SB).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=406327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus vannielii SB.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in F420 biosynthesis through the oxidation of
CC       lactaldehyde to lactate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:14277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:18041, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.22;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000742; ABR54702.1; -; Genomic_DNA.
DR   RefSeq; WP_011972604.1; NC_009634.1.
DR   AlphaFoldDB; A6UQD0; -.
DR   SMR; A6UQD0; -.
DR   STRING; 406327.Mevan_0796; -.
DR   EnsemblBacteria; ABR54702; ABR54702; Mevan_0796.
DR   GeneID; 5324651; -.
DR   KEGG; mvn:Mevan_0796; -.
DR   eggNOG; arCOG01252; Archaea.
DR   HOGENOM; CLU_005391_1_0_2; -.
DR   OMA; WHKLIEQ; -.
DR   OrthoDB; 42527at2157; -.
DR   UniPathway; UPA00071; -.
DR   Proteomes; UP000001107; Chromosome.
DR   GO; GO:0008911; F:lactaldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           1..465
FT                   /note="Lactaldehyde dehydrogenase"
FT                   /id="PRO_0000342593"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        274
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         220..225
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   465 AA;  51019 MW;  DDDDAE5D57893F99 CRC64;
     MFIDGKWILR EDLDILNPYT LEIIERITAL DREETKYAIE VATENKDVMK ELNPSKRYSL
     LMKIAEHISS KKDLFANTIS VDVGKPIKQS RIEVDRTITA FRLSALYAKE LRGETIPSEN
     EIIFTKKEPV GVVGAITPFN FPLNLITHKI GPAIATGNAV VLHPSSKAPI TAIYLTKVIE
     HVLKKMNIER GVFNLTTGNG EIVGDEIAKN EKINFLSFTG SVEVGELISK SSYMKKVALE
     LGGNNPLIVL KDSDIELAAK SAVKSKFLNS GQVCISVGKV IVEEEVLETF TKKVIEETKK
     LVLGNPLDEK TDLGPLITPE SALRVEILIK ESISEGGELL IGGNRSNSLI SPAVLNIDED
     NILSKVEAFG PILPILKAKD DEHALNIANN SKYGLQAGIF TNDINKAMKF ANKLEYGGVI
     VNGSPTFRKD NMPFGGIKKS GLGKEGIKYA VEEMCETKTV VIHNM