ID   LAFT_VIBPA              Reviewed;         285 AA.
AC   Q03477;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Chemotaxis protein LafT;
GN   Name=lafT; OrderedLocusNames=VPA1556;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB22;
RX   PubMed=8501040; DOI=10.1128/jb.175.11.3361-3371.1993;
RA   McCarter L.L., Wright M.E.;
RT   "Identification of genes encoding components of the swarmer cell flagellar
RT   motor and propeller and a sigma factor controlling differentiation of
RT   Vibrio parahaemolyticus.";
RL   J. Bacteriol. 175:3361-3371(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: Required for rotation of the flagellar motor. Probable
CC       transmembrane proton channel.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: Under conditions in which the polar flagellum is not
CC       functional.
CC   -!- SIMILARITY: Belongs to the MotA family. {ECO:0000305}.
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DR   EMBL; U20541; AAA62354.1; -; Genomic_DNA.
DR   EMBL; U52957; AAB07357.1; -; Genomic_DNA.
DR   EMBL; BA000032; BAC62899.1; -; Genomic_DNA.
DR   PIR; E40590; E40590.
DR   RefSeq; NP_801066.1; NC_004605.1.
DR   RefSeq; WP_005462768.1; NC_004605.1.
DR   AlphaFoldDB; Q03477; -.
DR   SMR; Q03477; -.
DR   STRING; 223926.28809958; -.
DR   EnsemblBacteria; BAC62899; BAC62899; BAC62899.
DR   GeneID; 1192252; -.
DR   KEGG; vpa:VPA1556; -.
DR   PATRIC; fig|223926.6.peg.4478; -.
DR   eggNOG; COG1291; Bacteria.
DR   HOGENOM; CLU_068213_0_0_6; -.
DR   OMA; MGIIITM; -.
DR   Proteomes; UP000002493; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097588; P:archaeal or bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000540; Flag_MotA_CS.
DR   InterPro; IPR022522; Flagellar_motor_stator_MotA.
DR   InterPro; IPR002898; MotA_ExbB_proton_chnl.
DR   PANTHER; PTHR30433:SF4; PTHR30433:SF4; 1.
DR   Pfam; PF01618; MotA_ExbB; 1.
DR   TIGRFAMs; TIGR03818; MotA1; 1.
DR   PROSITE; PS01307; MOTA; 1.
PE   2: Evidence at transcript level;
KW   Cell inner membrane; Cell membrane; Chemotaxis; Flagellar rotation;
KW   Hydrogen ion transport; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..285
FT                   /note="Chemotaxis protein LafT"
FT                   /id="PRO_0000189581"
FT   TRANSMEM        4..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..285
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   285 AA;  31325 MW;  56C6210F8A8DB652 CRC64;
     MQKFLGVLTI LVCVFGGYMW AGGKLGAIWQ PAEFLIIIGA AAGSLIIGNP PHVLKEMRQQ
     VPATIKGPTE EYEYYMELMA LLNNLLETAR SRGFKFLDSH IEAPEQSSIF LMYPLVSEDH
     RLISFITDNL RLMAMGQMSP HELEGLLEQE IEAIQNELLL PSRSLQRTAE ALPGFGILAA
     VGGIIITMQA IDGSIALIGY HVAAALVGTF IGIFGCYCGL DPLSNAMAQR VKRNMTAFEC
     VRATLVAYVA KKPTLLAIDA GRKHIQLDIK PTFNQMEKWL AEQEG