LAFU_ECO44
ID LAFU_ECO44 Reviewed; 307 AA.
AC D3GSC3; Q5DXZ5;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Putative flagellar export/assembly protein LafU {ECO:0000305};
GN Name=lafU {ECO:0000303|PubMed:15687208};
GN OrderedLocusNames=EC042_0288 {ECO:0000312|EMBL:CBG33121.1};
GN ORFNames=Ec042-0288 {ECO:0000312|EMBL:CAH19156.1};
OS Escherichia coli O44:H18 (strain 042 / EAEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=216592;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=042 / EAEC;
RX PubMed=15687208; DOI=10.1128/jb.187.4.1430-1440.2005;
RA Ren C.-P., Beatson S.A., Parkhill J., Pallen M.J.;
RT "The Flag-2 locus, an ancestral gene cluster, is potentially associated
RT with a novel flagellar system from Escherichia coli.";
RL J. Bacteriol. 187:1430-1440(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=042 / EAEC;
RX PubMed=20098708; DOI=10.1371/journal.pone.0008801;
RA Chaudhuri R.R., Sebaihia M., Hobman J.L., Webber M.A., Leyton D.L.,
RA Goldberg M.D., Cunningham A.F., Scott-Tucker A., Ferguson P.R.,
RA Thomas C.M., Frankel G., Tang C.M., Dudley E.G., Roberts I.S., Rasko D.A.,
RA Pallen M.J., Parkhill J., Nataro J.P., Thomson N.R., Henderson I.R.;
RT "Complete genome sequence and comparative metabolic profiling of the
RT prototypical enteroaggregative Escherichia coli strain 042.";
RL PLoS ONE 5:E8801-E8801(2010).
CC -!- FUNCTION: Part of the flagellar gene cluster Flag-2. However, the Flag-
CC 2 flagellar system could be inactive in strain 042 due to a frameshift
CC in lfgC. {ECO:0000305|PubMed:15687208}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the MotB family. {ECO:0000305}.
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DR EMBL; CR753847; CAH19156.1; -; Genomic_DNA.
DR EMBL; FN554766; CBG33121.1; -; Genomic_DNA.
DR RefSeq; WP_001232553.1; NC_017626.1.
DR AlphaFoldDB; D3GSC3; -.
DR SMR; D3GSC3; -.
DR KEGG; elo:EC042_0288; -.
DR PATRIC; fig|216592.3.peg.304; -.
DR HOGENOM; CLU_016890_3_2_6; -.
DR OMA; FMVLWIM; -.
DR Proteomes; UP000001407; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07185; OmpA_C-like; 1.
DR Gene3D; 3.30.1330.60; -; 1.
DR InterPro; IPR025713; MotB_N_dom.
DR InterPro; IPR006665; OmpA-like.
DR InterPro; IPR036737; OmpA-like_sf.
DR Pfam; PF13677; MotB_plug; 1.
DR Pfam; PF00691; OmpA; 1.
DR SUPFAM; SSF103088; SSF103088; 1.
DR PROSITE; PS51123; OMPA_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..307
FT /note="Putative flagellar export/assembly protein LafU"
FT /id="PRO_0000432476"
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 154..272
FT /note="OmpA-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00473"
FT REGION 87..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 34227 MW; 77C4F7E1F0A40FAC CRC64;
MRKTGNRRER GAKTTIVRRQ IKKNHAGHHG GAWKVAFADF TLAMMALFMT LWIVNSVSKS
ERESIIAALH GQSIFNGGGL SPLNKISPSH PPKPATVAAP EETEKKARDV NEKTALLKKK
SATELGELAT SINTIARDAH MEANLEMEIV PQGLRVLIKD DQNRNMFERG SAQIMPFFKT
LLVELAPVFD SLDNKIIITG HTDAMAYKNN IYNNWNLSGD RALSARRVLE EAGMPEDKVM
QVSAMADQML LDAKNPQSAG NRRIEIMVLT KSASDTLYQY FGQHGDKVVQ PLVQKLDKQQ
VHSQRTR
