ID   LAFX_LACJO              Reviewed;          62 AA.
AC   Q48509;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Bacteriocin lactacin-F subunit LafX;
DE   Flags: Precursor;
GN   Name=lafX; OrderedLocusNames=LJ_0769.1; ORFNames=LJ_0769b;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11506 / JCM 1101 / NBRC 13952 / NCIMB 8795 / R-26 / VPI 11088;
RX   PubMed=8285694; DOI=10.1128/aem.59.11.3906-3915.1993;
RA   Fremaux C., Ahn C., Klaenhammer T.R.;
RT   "Molecular analysis of the lactacin F operon.";
RL   Appl. Environ. Microbiol. 59:3906-3915(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: Heat stable bacteriocin active against Enterococcus faecalis
CC       and other Lactobacilli.
CC   -!- SUBUNIT: This bacteriocin depends upon the complementation of two
CC       peptides for activity: LafA and LafX. Associated with a 180 kDa
CC       bacteriocin complex.
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIB family. {ECO:0000305}.
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DR   EMBL; M57961; AAA16637.1; -; Unassigned_DNA.
DR   EMBL; AE017198; AAS08589.1; -; Genomic_DNA.
DR   RefSeq; WP_011161712.1; NC_005362.1.
DR   AlphaFoldDB; Q48509; -.
DR   SMR; Q48509; -.
DR   STRING; 257314.LJ_0769b; -.
DR   EnsemblBacteria; AAS08589; AAS08589; LJ_0769b.
DR   GeneID; 64333379; -.
DR   KEGG; ljo:LJ_0769b; -.
DR   HOGENOM; CLU_171152_1_0_9; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR019493; Bacteriocin_IIb_lactacin-rel.
DR   InterPro; IPR010133; Bacteriocin_signal_seq.
DR   Pfam; PF10439; Bacteriocin_IIc; 1.
DR   TIGRFAMs; TIGR01847; bacteriocin_sig; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriocin; Reference proteome.
FT   PROPEP          1..14
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000002755"
FT   CHAIN           15..62
FT                   /note="Bacteriocin lactacin-F subunit LafX"
FT                   /id="PRO_0000002756"
SQ   SEQUENCE   62 AA;  6250 MW;  B8EB8BE795830716 CRC64;
     MKLNDKELSK IVGGNRWGDT VLSAASGAGT GIKACKSFGP WGMAICGVGG AAIGGYFGYT
     HN