LAIR2_HUMAN
ID LAIR2_HUMAN Reviewed; 152 AA.
AC Q6ISS4; Q6PEZ4;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Leukocyte-associated immunoglobulin-like receptor 2;
DE Short=LAIR-2;
DE AltName: CD_antigen=CD306;
DE Flags: Precursor;
GN Name=LAIR2; Synonyms=CD306;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=9285412; DOI=10.1016/s1074-7613(00)80530-0;
RA Meyaard L., Adema G.J., Chang C., Woollatt E., Sutherland G.R.,
RA Lanier L.L., Phillips J.H.;
RT "LAIR-1, a novel inhibitory receptor expressed on human mononuclear
RT leukocytes.";
RL Immunity 7:283-290(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10229813;
RA Meyaard L., Hurenkamp J., Clevers H., Lanier L.L., Phillips J.H.;
RT "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory
RT receptor on cytotoxic T cells.";
RL J. Immunol. 162:5800-5804(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6ISS4; Q9Y6C2: EMILIN1; NbExp=3; IntAct=EBI-10250491, EBI-744586;
CC Q6ISS4; Q9Y6C2-2: EMILIN1; NbExp=3; IntAct=EBI-10250491, EBI-11748557;
CC Q6ISS4; P80188: LCN2; NbExp=3; IntAct=EBI-10250491, EBI-11911016;
CC Q6ISS4; O43765: SGTA; NbExp=6; IntAct=EBI-10250491, EBI-347996;
CC Q6ISS4; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10250491, EBI-741480;
CC Q6ISS4; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-10250491, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=LAIR-2a;
CC IsoId=Q6ISS4-1; Sequence=Displayed;
CC Name=2; Synonyms=LAIR-2b;
CC IsoId=Q6ISS4-2; Sequence=VSP_020720;
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DR EMBL; AF013250; AAB69325.1; -; mRNA.
DR EMBL; AA133246; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC069366; AAH69366.1; -; mRNA.
DR CCDS; CCDS12897.1; -. [Q6ISS4-1]
DR CCDS; CCDS12898.1; -. [Q6ISS4-2]
DR RefSeq; NP_002279.2; NM_002288.5. [Q6ISS4-1]
DR RefSeq; NP_067154.1; NM_021270.4. [Q6ISS4-2]
DR AlphaFoldDB; Q6ISS4; -.
DR SMR; Q6ISS4; -.
DR BioGRID; 110099; 49.
DR IntAct; Q6ISS4; 5.
DR STRING; 9606.ENSP00000301202; -.
DR iPTMnet; Q6ISS4; -.
DR PhosphoSitePlus; Q6ISS4; -.
DR BioMuta; LAIR2; -.
DR DMDM; 74736630; -.
DR jPOST; Q6ISS4; -.
DR MassIVE; Q6ISS4; -.
DR MaxQB; Q6ISS4; -.
DR PaxDb; Q6ISS4; -.
DR PeptideAtlas; Q6ISS4; -.
DR PRIDE; Q6ISS4; -.
DR ProteomicsDB; 66494; -. [Q6ISS4-1]
DR ProteomicsDB; 66495; -. [Q6ISS4-2]
DR Antibodypedia; 32926; 220 antibodies from 24 providers.
DR DNASU; 3904; -.
DR Ensembl; ENST00000301202.7; ENSP00000301202.2; ENSG00000167618.10. [Q6ISS4-1]
DR Ensembl; ENST00000351841.2; ENSP00000301203.2; ENSG00000167618.10. [Q6ISS4-2]
DR Ensembl; ENST00000612901.4; ENSP00000478193.1; ENSG00000274084.4. [Q6ISS4-1]
DR Ensembl; ENST00000620256.4; ENSP00000477747.1; ENSG00000274084.4. [Q6ISS4-2]
DR Ensembl; ENST00000621280.1; ENSP00000480904.1; ENSG00000277335.4. [Q6ISS4-2]
DR Ensembl; ENST00000622556.4; ENSP00000477535.1; ENSG00000277335.4. [Q6ISS4-1]
DR GeneID; 3904; -.
DR KEGG; hsa:3904; -.
DR MANE-Select; ENST00000301202.7; ENSP00000301202.2; NM_002288.6; NP_002279.2.
DR UCSC; uc002qgc.4; human. [Q6ISS4-1]
DR CTD; 3904; -.
DR DisGeNET; 3904; -.
DR GeneCards; LAIR2; -.
DR HGNC; HGNC:6478; LAIR2.
DR HPA; ENSG00000167618; Tissue enhanced (lymphoid tissue, pituitary gland).
DR MIM; 602993; gene.
DR neXtProt; NX_Q6ISS4; -.
DR OpenTargets; ENSG00000167618; -.
DR PharmGKB; PA30267; -.
DR VEuPathDB; HostDB:ENSG00000167618; -.
DR eggNOG; ENOG502TBGD; Eukaryota.
DR GeneTree; ENSGT01000000214458; -.
DR HOGENOM; CLU_021100_7_1_1; -.
DR InParanoid; Q6ISS4; -.
DR OMA; ENRSQYK; -.
DR OrthoDB; 1481318at2759; -.
DR PhylomeDB; Q6ISS4; -.
DR TreeFam; TF336644; -.
DR PathwayCommons; Q6ISS4; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q6ISS4; -.
DR BioGRID-ORCS; 3904; 12 hits in 987 CRISPR screens.
DR GeneWiki; LAIR2; -.
DR GenomeRNAi; 3904; -.
DR Pharos; Q6ISS4; Tbio.
DR PRO; PR:Q6ISS4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ISS4; protein.
DR Bgee; ENSG00000167618; Expressed in granulocyte and 92 other tissues.
DR ExpressionAtlas; Q6ISS4; baseline and differential.
DR Genevisible; Q6ISS4; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Immunoglobulin domain; Receptor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..152
FT /note="Leukocyte-associated immunoglobulin-like receptor 2"
FT /id="PRO_0000250685"
FT DOMAIN 29..117
FT /note="Ig-like C2-type"
FT REGION 120..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 49..101
FT /evidence="ECO:0000250"
FT VAR_SEQ 122..138
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9285412"
FT /id="VSP_020720"
FT VARIANT 78
FT /note="G -> S (in dbSNP:rs36121405)"
FT /id="VAR_049882"
FT VARIANT 87
FT /note="H -> R (in dbSNP:rs34423078)"
FT /id="VAR_049883"
FT VARIANT 115
FT /note="F -> Y (in dbSNP:rs34429135)"
FT /id="VAR_049884"
SQ SEQUENCE 152 AA; 16280 MW; 8097688A9DB42EC8 CRC64;
MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL
EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV
KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP
