ID   LALBA_FELCA             Reviewed;          24 AA.
AC   P37154;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Alpha-lactalbumin;
DE   AltName: Full=Lactose synthase B protein;
DE   Flags: Fragment;
GN   Name=LALBA;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Milk;
RX   PubMed=2344734; DOI=10.1016/0305-0491(90)90316-l;
RA   Halliday J.A., Bell K., McKenzie H.A., Shaw D.C.;
RT   "Feline whey proteins: identification, isolation and initial
RT   characterization of alpha-lactalbumin, beta-lactoglobulin and lysozyme.";
RL   Comp. Biochem. Physiol. 95B:773-779(1990).
CC   -!- FUNCTION: Regulatory subunit of lactose synthase, changes the substrate
CC       specificity of galactosyltransferase in the mammary gland making
CC       glucose a good acceptor substrate for this enzyme. This enables LS to
CC       synthesize lactose, the major carbohydrate component of milk. In other
CC       tissues, galactosyltransferase transfers galactose onto the N-
CC       acetylglucosamine of the oligosaccharide chains in glycoproteins.
CC   -!- SUBUNIT: Lactose synthase (LS) is a heterodimer of a catalytic
CC       component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory
CC       component, alpha-lactalbumin (LA).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- PTM: Glycosylated (50% of the proteins).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family. {ECO:0000305}.
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DR   PIR; C60525; C60525.
DR   AlphaFoldDB; P37154; -.
DR   STRING; 9685.ENSFCAP00000010481; -.
DR   eggNOG; ENOG502T8BJ; Eukaryota.
DR   TreeFam; TF324882; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005989; P:lactose biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001916; Glyco_hydro_22.
DR   Pfam; PF00062; Lys; 1.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Glycoprotein; Lactose biosynthesis;
KW   Milk protein; Reference proteome; Secreted.
FT   CHAIN           1..>24
FT                   /note="Alpha-lactalbumin"
FT                   /id="PRO_0000208835"
FT   NON_TER         24
SQ   SEQUENCE   24 AA;  2642 MW;  F41D1EA737220CA1 CRC64;
     KQFTKCELSQ VLKDMDGYGG IALP