LAMB2_YERPE
ID LAMB2_YERPE Reviewed; 419 AA.
AC Q8ZHP0; Q0WII7;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Maltoporin-2;
DE AltName: Full=Maltose-inducible porin 2;
DE Flags: Precursor;
GN Name=lamB2; OrderedLocusNames=YPO0850, y3235, YP_3547;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Involved in the transport of maltose and maltodextrins.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer formed of three 18-stranded antiparallel beta-
CC barrels, containing three independent channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- INDUCTION: By maltose. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the porin LamB (TC 1.B.3) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM86785.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS63700.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL19520.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86785.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS63700.1; ALT_INIT; Genomic_DNA.
DR PIR; AF0104; AF0104.
DR RefSeq; WP_002215759.1; NZ_WUCM01000018.1.
DR RefSeq; YP_002345901.1; NC_003143.1.
DR AlphaFoldDB; Q8ZHP0; -.
DR SMR; Q8ZHP0; -.
DR STRING; 214092.YPO0850; -.
DR PaxDb; Q8ZHP0; -.
DR EnsemblBacteria; AAM86785; AAM86785; y3235.
DR EnsemblBacteria; AAS63700; AAS63700; YP_3547.
DR GeneID; 57973789; -.
DR KEGG; ype:YPO0850; -.
DR KEGG; ypk:y3235; -.
DR KEGG; ypm:YP_3547; -.
DR PATRIC; fig|214092.21.peg.1119; -.
DR eggNOG; COG4580; Bacteria.
DR HOGENOM; CLU_032473_4_1_6; -.
DR OMA; YYTYASW; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0045203; C:integral component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0046930; C:pore complex; IBA:GO_Central.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042958; F:maltodextrin transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015481; F:maltose transporting porin activity; IEA:InterPro.
DR GO; GO:0015288; F:porin activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0015774; P:polysaccharide transport; IBA:GO_Central.
DR CDD; cd01346; Maltoporin-like; 1.
DR Gene3D; 2.40.170.10; -; 1.
DR HAMAP; MF_01301; LamB; 1.
DR InterPro; IPR023738; Maltoporin.
DR InterPro; IPR003192; Porin_LamB.
DR InterPro; IPR036998; Porin_LamB_sf.
DR Pfam; PF02264; LamB; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Ion transport; Membrane; Porin; Reference proteome;
KW Signal; Sugar transport; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..419
FT /note="Maltoporin-2"
FT /id="PRO_0000025182"
FT SITE 32
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 63
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 250
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 378
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000255"
FT SITE 418
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT CONFLICT 339
FT /note="R -> C (in Ref. 3; AAS63700)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 46264 MW; A14220470B99D3E4 CRC64;
MKTSLRTLSV ALAAALVSPS VLAIEKIDFH GYMRAGVGVS SDGGLAEWQK TMVGRLGNES
DTYGEIGLGA EVYKKEDVSF YLDSMVSMLS DGSNDSETTI GDDAQFGLRQ LNLQIKGLIP
GDKEAVIWGG KRYYQRHDLH IIDTKYWNIS GSGAGIENYT VGPGAVSVAW VRGDANDVDT
RITGDSDVNI NYIDVRYAGF KPWAGSWTEV GIDYAMPNPT KQQKEYGGLY DADNAVMLTG
EISQDMFGGY NKLVLQYANK GLAQNMISQG GGWYDMWHKT DEAKGYRVIN TGLIPITDKF
SFNHVLTWGS ANDITEYTDK TNLISLVGRA QYQFTQYVRA IGEVGGFYQK DTYHNGSNYK
QGGEKYTIAL GLAEGPDFLS RPELRVFASY LNDSENGKPF EDGTSNDTWN FGVQVEAWW
