ARCH_METTH
ID ARCH_METTH Reviewed; 140 AA.
AC O27635;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein archease {ECO:0000255|HAMAP-Rule:MF_01222};
GN OrderedLocusNames=MTH_1598;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
RN [2]
RP PRELIMINARY FUNCTION.
RX PubMed=15162483; DOI=10.1002/prot.20141;
RA Canaves J.M.;
RT "Predicted role for the archease protein family based on structural and
RT sequence analysis of TM1083 and MTH1598, two proteins structurally
RT characterized through structural genomics efforts.";
RL Proteins 56:19-27(2004).
RN [3]
RP STRUCTURE BY NMR.
RX PubMed=11854485; DOI=10.1073/pnas.042684599;
RA Yee A., Chang X., Pineda-Lucena A., Wu B., Semesi A., Le B., Ramelot T.,
RA Lee G.M., Bhattacharyya S., Gutierrez P., Denisov A., Lee C.-H., Cort J.R.,
RA Kozlov G., Liao J., Finak G., Chen L., Wishart D., Lee W., McIntosh L.P.,
RA Gehring K., Kennedy M.A., Edwards A.M., Arrowsmith C.H.;
RT "An NMR approach to structural proteomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:1825-1830(2002).
CC -!- FUNCTION: Activates the tRNA-splicing ligase complex by facilitating
CC the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the
CC guanylylation of RtcB, a key intermediate step in tRNA ligation. Can
CC also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is
CC used efficiently (By similarity). May also act as a chaperone or
CC modulator of proteins involved in DNA or RNA processing. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archease family. {ECO:0000255|HAMAP-
CC Rule:MF_01222}.
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DR EMBL; AE000666; AAB86071.1; -; Genomic_DNA.
DR PIR; C69080; C69080.
DR RefSeq; WP_010877206.1; NC_000916.1.
DR PDB; 1JW3; NMR; -; A=1-140.
DR PDBsum; 1JW3; -.
DR AlphaFoldDB; O27635; -.
DR BMRB; O27635; -.
DR SMR; O27635; -.
DR STRING; 187420.MTH_1598; -.
DR EnsemblBacteria; AAB86071; AAB86071; MTH_1598.
DR GeneID; 1471867; -.
DR KEGG; mth:MTH_1598; -.
DR PATRIC; fig|187420.15.peg.1561; -.
DR HOGENOM; CLU_111362_3_0_2; -.
DR OMA; WLSELLY; -.
DR EvolutionaryTrace; O27635; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.55.10.10; -; 1.
DR HAMAP; MF_01222; Archease_arch; 1.
DR InterPro; IPR002804; Archease.
DR InterPro; IPR022952; Archease_arc.
DR InterPro; IPR023572; Archease_dom.
DR InterPro; IPR036820; Archease_dom_sf.
DR PANTHER; PTHR12682; PTHR12682; 1.
DR Pfam; PF01951; Archease; 1.
DR SUPFAM; SSF69819; SSF69819; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Metal-binding; Reference proteome; tRNA processing.
FT CHAIN 1..140
FT /note="Protein archease"
FT /id="PRO_0000068846"
FT BINDING 12
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 139
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 140
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT STRAND 4..6
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 10..18
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 20..22
FT /evidence="ECO:0007829|PDB:1JW3"
FT HELIX 23..37
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 48..58
FT /evidence="ECO:0007829|PDB:1JW3"
FT HELIX 59..75
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 84..89
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 91..101
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 124..128
FT /evidence="ECO:0007829|PDB:1JW3"
FT STRAND 131..139
FT /evidence="ECO:0007829|PDB:1JW3"
SQ SEQUENCE 140 AA; 16183 MW; 1F82F57056E55AFC CRC64;
MKGFEFFDVT ADAGFWAYGH DLEEVFENAA LAMFEVMTDT SLVEAAEERR VEITSEDRVS
LLYDWLDELL FIHDTEFILF SKFKVKIDEK DDGLHLTGTA MGEEIKEGHE RRDEVKAVTF
HMMEILDEDG LIKARVILDL
