LAMBV_CHICK
ID LAMBV_CHICK Reviewed; 198 AA.
AC Q01636;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Laminin subunit beta-1 variant;
DE AltName: Full=Laminin beta-1-2 chain;
DE Flags: Fragment;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eye;
RX PubMed=1400373; DOI=10.1016/s0021-9258(19)36720-1;
RA O'Rear J.J.;
RT "A novel laminin B1 chain variant in avian eye.";
RL J. Biol. Chem. 267:20555-20557(1992).
CC -!- FUNCTION: Binding to cells via a high affinity receptor, laminin is
CC thought to mediate the attachment, migration and organization of cells
CC into tissues during embryonic development by interacting with other
CC extracellular matrix components.
CC -!- SUBUNIT: Laminin is a complex glycoprotein, consisting of three
CC different polypeptide chains (alpha, beta, gamma), which are bound to
CC each other by disulfide bonds into a cross-shaped molecule comprising
CC one long and three short arms with globules at each end.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane. Note=Major component.
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DR EMBL; L00963; AAA49140.1; -; mRNA.
DR PIR; A45067; A45067.
DR AlphaFoldDB; Q01636; -.
DR SMR; Q01636; -.
DR VEuPathDB; HostDB:geneid_373980; -.
DR PhylomeDB; Q01636; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR InterPro; IPR008211; Laminin_N.
DR Pfam; PF00055; Laminin_N; 1.
DR SMART; SM00136; LamNT; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 2: Evidence at transcript level;
KW Basement membrane; Cell adhesion; Disulfide bond; Extracellular matrix;
KW Laminin EGF-like domain; Reference proteome; Secreted.
FT CHAIN <1..>198
FT /note="Laminin subunit beta-1 variant"
FT /id="PRO_0000086854"
FT DOMAIN 83..>198
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00466"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..62
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 198
SQ SEQUENCE 198 AA; 21830 MW; 6FD669761892C442 CRC64;
AATTLRRGGG REPTPPATPP THARPDPTRR HPDPESRAPP HARPRSPPPP APSPPPLPPR
PAAVRAGRDR VGRVFSRLPP GCAAGSCYPA TGDLLVGRAP RLSASSTCGL RRPQPYCIVS
HLQEEKKCFI CDSRRPYDAR SNTDSHRIEN VLTTFAPRPK KAWWQAENGV EHVSIQLDLE
AEFHFTHLIM TFKTFRPA