ID   LAMB_AERHY              Reviewed;         434 AA.
AC   Q8KKH0; Q8KKH1;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Maltoporin;
DE   AltName: Full=Maltose-inducible porin;
DE   Flags: Precursor;
GN   Name=lamB; Synonyms=lamB1, lamB2;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EUS112;
RA   Upadhyaya T., Singh R.K., Dixit A.;
RT   "Cloning and characterization of lamB gene of Aeromonas hydrophila.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the transport of maltose and maltodextrins.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer formed of three 18-stranded antiparallel beta-
CC       barrels, containing three independent channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8KKH0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8KKH0-2; Sequence=VSP_018984;
CC   -!- INDUCTION: By maltose. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform 2]: Contains a signal peptide at positions 1-
CC       22. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the porin LamB (TC 1.B.3) family. {ECO:0000305}.
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DR   EMBL; AJ493581; CAD43291.2; -; Genomic_DNA.
DR   EMBL; AJ493581; CAD43292.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q8KKH0; -.
DR   SMR; Q8KKH0; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0042958; F:maltodextrin transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015481; F:maltose transporting porin activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd01346; Maltoporin-like; 1.
DR   Gene3D; 2.40.170.10; -; 1.
DR   HAMAP; MF_01301; LamB; 1.
DR   InterPro; IPR023738; Maltoporin.
DR   InterPro; IPR003192; Porin_LamB.
DR   InterPro; IPR036998; Porin_LamB_sf.
DR   Pfam; PF02264; LamB; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Cell outer membrane; Ion transport; Membrane;
KW   Porin; Signal; Sugar transport; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..434
FT                   /note="Maltoporin"
FT                   /id="PRO_0000237574"
FT   SITE            31
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   SITE            62
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   SITE            95
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   SITE            154
FT                   /note="Important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   SITE            262
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   SITE            391
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   SITE            433
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..2
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018984"
SQ   SEQUENCE   434 AA;  48024 MW;  D401671C8A0C61F8 CRC64;
     MKMKAKWLPI AAAVTAALAS QAAFAVDFHG YFRSGVGVSS DGDMQTLSKQ KVGRLGNEDD
     TYGEVQLGQE VFNKDGKTFY VDSMFAMIPN GSNDWEGTGS VCNFDEKQCS GDSEFALRQF
     NVQAKGLLGF APEATLWAGK RYYQRHDIHI SDFYYWNISG AGAGIEGVQA GPGKISFAWV
     RNDRGWDGKD GWTKFEGMDV NTLDLRYAGI PLWQDASLEV GVDYAIANPT DAQKDSSNVQ
     YKNAKDGVML TAELTQGIFG GFNKTVLQYG TEGYSKTMAF YGDGSWYGAE AKDGADGFRI
     INHGVIPMGN SWEMGHQLVY GVGNDMWDGN DKWETMSVVA RPMYKWDDFN KTIFEGGYFK
     DKNKSTNGSS LEDSGYKLTL SQTWSAGSSF WARPEIRVFT SYAALDDNDM AGTPYNSKTS
     KDTWNFGVQA EAWW