ID   LAMB_ECOUT              Reviewed;         446 AA.
AC   Q1R3Q0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Maltoporin {ECO:0000255|HAMAP-Rule:MF_01301};
DE   AltName: Full=Maltose-inducible porin {ECO:0000255|HAMAP-Rule:MF_01301};
DE   Flags: Precursor;
GN   Name=lamB {ECO:0000255|HAMAP-Rule:MF_01301}; OrderedLocusNames=UTI89_C4606;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Involved in the transport of maltose and maltodextrins.
CC       {ECO:0000255|HAMAP-Rule:MF_01301}.
CC   -!- SUBUNIT: Homotrimer formed of three 18-stranded antiparallel beta-
CC       barrels, containing three independent channels. {ECO:0000255|HAMAP-
CC       Rule:MF_01301}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01301}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01301}.
CC   -!- INDUCTION: By maltose. {ECO:0000255|HAMAP-Rule:MF_01301}.
CC   -!- SIMILARITY: Belongs to the porin LamB (TC 1.B.3) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01301}.
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DR   EMBL; CP000243; ABE10014.1; -; Genomic_DNA.
DR   RefSeq; WP_000973666.1; NC_007946.1.
DR   AlphaFoldDB; Q1R3Q0; -.
DR   SMR; Q1R3Q0; -.
DR   EnsemblBacteria; ABE10014; ABE10014; UTI89_C4606.
DR   KEGG; eci:UTI89_C4606; -.
DR   HOGENOM; CLU_032473_4_1_6; -.
DR   OMA; DYGRANA; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0042958; F:maltodextrin transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015481; F:maltose transporting porin activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd01346; Maltoporin-like; 1.
DR   Gene3D; 2.40.170.10; -; 1.
DR   HAMAP; MF_01301; LamB; 1.
DR   InterPro; IPR023738; Maltoporin.
DR   InterPro; IPR003192; Porin_LamB.
DR   InterPro; IPR036998; Porin_LamB_sf.
DR   Pfam; PF02264; LamB; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW   Sugar transport; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   CHAIN           26..446
FT                   /note="Maltoporin"
FT                   /id="PRO_0000290217"
FT   SITE            31
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            66
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            99
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            143
FT                   /note="Important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            252
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            383
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            445
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
SQ   SEQUENCE   446 AA;  49941 MW;  66AD83740268B030 CRC64;
     MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQT TGAQSKYRLG
     NECETYAELK LGQEVWKEGD KSFYFDTNVA YSVAQQNDWE ATDPAFREAN VQGKNLIEWL
     PGSTIWAGKR FYQRHDVHMI DFYYWDISGP GAGLENIDVG FGKLSLAATR SSEAGGSSSF
     ASNNIYDYTN ETANDVFDVR LAQMEINPGG TLELGVDYGR ANLRDNYRLV DGASKDGWLF
     TAEHTQSVLK GFNKFVVQYA TDSMTSQGKG LSQGSGVAFD NEKFAYNINN NGHMLRILDH
     GAISMGDNWD MMYVGMYQDI NWDNDNGTKW WTVGIRPMYK WTPIMSTVME IGYDNVESQR
     TGDKNNQYKI TLAQQWQAGD SIWSRPAIRV FATYAKWDEK WGYDYTGSSS TNPYYGKAVS
     ADFNGGSFGR GDSDEWTFGA QMEIWW