LAMB_EMENI
ID LAMB_EMENI Reviewed; 253 AA.
AC P38096; C8VPY3; Q5BEZ4;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Lactam utilization protein lamB;
GN Name=lamB; ORFNames=AN0886;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=biA1 niiA4;
RX PubMed=1729609; DOI=10.1128/mcb.12.1.337-346.1992;
RA Richardson I.B., Katz M.E., Hynes M.J.;
RT "Molecular characterization of the lam locus and sequences involved in
RT regulation by the AmdR protein of Aspergillus nidulans.";
RL Mol. Cell. Biol. 12:337-346(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [4]
RP FUNCTION.
RX PubMed=368580; DOI=10.1007/bf00267625;
RA Arst H.N. Jr., Penfold H.A., Bailey C.R.;
RT "Lactam utilisation in Aspergillus nidulans: evidence for a fourth gene
RT under the control of the integrator gene intA.";
RL Mol. Gen. Genet. 166:321-327(1978).
RN [5]
RP FUNCTION.
RX PubMed=2670678; DOI=10.1016/0378-1119(89)90324-7;
RA Katz M.E., Hynes M.J.;
RT "Gene function identified by interspecific transformation.";
RL Gene 78:167-171(1989).
RN [6]
RP FUNCTION, AND INDUCTION.
RX PubMed=2670667; DOI=10.1093/genetics/122.2.331;
RA Katz M.E., Hynes M.J.;
RT "Characterization of the amdR-controlled lamA and lamB genes of Aspergillus
RT nidulans.";
RL Genetics 122:331-339(1989).
CC -!- FUNCTION: Involved in the utilization of lactams. Required for the
CC conversion of exogenous 2-pyrrolidinone (gamma-butyrolactam) to
CC endogenous gamma-amino-n-butyrate (GABA). {ECO:0000269|PubMed:2670667,
CC ECO:0000269|PubMed:2670678, ECO:0000269|PubMed:368580}.
CC -!- INDUCTION: By beta-alanine. {ECO:0000269|PubMed:2670667}.
CC -!- SIMILARITY: Belongs to the LamB/PxpA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA33313.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M77283; AAA33313.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AACD01000014; EAA65915.1; -; Genomic_DNA.
DR EMBL; BN001308; CBF88590.1; -; Genomic_DNA.
DR PIR; B42064; B42064.
DR RefSeq; XP_658490.1; XM_653398.1.
DR AlphaFoldDB; P38096; -.
DR SMR; P38096; -.
DR STRING; 162425.CADANIAP00001771; -.
DR EnsemblFungi; CBF88590; CBF88590; ANIA_00886.
DR EnsemblFungi; EAA65915; EAA65915; AN0886.2.
DR GeneID; 2876665; -.
DR KEGG; ani:AN0886.2; -.
DR VEuPathDB; FungiDB:AN0886; -.
DR eggNOG; ENOG502S0UZ; Eukaryota.
DR HOGENOM; CLU_069535_1_0_1; -.
DR InParanoid; P38096; -.
DR OMA; MPGSVIC; -.
DR OrthoDB; 1349970at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IMP:AspGD.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR005501; LamB/YcsF/PxpA-like.
DR PANTHER; PTHR30292; PTHR30292; 1.
DR Pfam; PF03746; LamB_YcsF; 1.
DR SUPFAM; SSF88713; SSF88713; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..253
FT /note="Lactam utilization protein lamB"
FT /id="PRO_0000185068"
SQ SEQUENCE 253 AA; 27946 MW; E858F5F940CB9001 CRC64;
MAPIKKKALI NCDMGEAYGN WTCGPDLELL PLIDIANIAC GFHAGDPLIM METVRNCKAH
NILVGAHPGL PDIQGFGRRE MKLSPEELTA ITIYQVGALQ GFLDREGVRL NHVKPHGVLY
GMMCRDYEVA KAVMLGIPKG IPVFGLPGTN MEKAANDLGI EFRAEFYGDV KYDSNGMLVI
DRKKKPWDPA DVEKHVRQQL EDQSVTSVDG VVVPLPIKDY DVSICCHSDS PGCLEIIKTT
KKVVDEFNKK YGF