LAMB_KLEPN
ID LAMB_KLEPN Reviewed; 429 AA.
AC P31242;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Maltoporin;
DE AltName: Full=Maltose-inducible porin;
DE Flags: Precursor;
GN Name=lamB;
OS Klebsiella pneumoniae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1033-5P14 / KAY2026;
RX PubMed=1535683; DOI=10.1007/bf00265433;
RA Werts C., Charbit A., Bachellier S., Hofnung M.;
RT "DNA sequence analysis of the lamB gene from Klebsiella pneumoniae:
RT implications for the topology and the pore functions in maltoporin.";
RL Mol. Gen. Genet. 233:372-378(1992).
CC -!- FUNCTION: Involved in the transport of maltose and maltodextrins. Does
CC not act as a receptor for phages.
CC -!- SUBUNIT: Homotrimer formed of three 18-stranded antiparallel beta-
CC barrels, containing three independent channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- INDUCTION: By maltose. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the porin LamB (TC 1.B.3) family. {ECO:0000305}.
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DR EMBL; X66952; CAA47377.1; -; Genomic_DNA.
DR PIR; S23581; S23581.
DR AlphaFoldDB; P31242; -.
DR SMR; P31242; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0042958; F:maltodextrin transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015481; F:maltose transporting porin activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR CDD; cd01346; Maltoporin-like; 1.
DR Gene3D; 2.40.170.10; -; 1.
DR HAMAP; MF_01301; LamB; 1.
DR InterPro; IPR023738; Maltoporin.
DR InterPro; IPR003192; Porin_LamB.
DR InterPro; IPR036998; Porin_LamB_sf.
DR Pfam; PF02264; LamB; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW Signal; Sugar transport; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..429
FT /note="Maltoporin"
FT /id="PRO_0000025178"
FT TOPO_DOM 26
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 27..35
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 36..64
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 65..78
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 79..80
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 81..93
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 94..104
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 105..115
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 116..122
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 123..130
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 131..148
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 149..159
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 160..161
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 162..173
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 174..191
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 192..205
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 206..209
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 210..222
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 223..234
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 235..248
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 249..250
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 251..263
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 264..279
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 280..294
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 295..296
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 297..312
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 313..315
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 316..330
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 331..332
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 333..348
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 349..351
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 352..367
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 368..374
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 375..389
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 390..413
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 414..428
FT /note="Beta stranded"
FT /evidence="ECO:0000250"
FT TOPO_DOM 429
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT REGION 397..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 31
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 66
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 99
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 143
FT /note="Important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 252
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 372
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT SITE 428
FT /note="Greasy slide, important in sugar transport"
FT /evidence="ECO:0000250"
FT DISULFID 47..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 429 AA; 47805 MW; C5A51C034A7193B2 CRC64;
MMITLRKLPL AVAVAAGVMS AQALAVDFHG YARSGIGWTG SGGEQQCFKA TGAQSKYRLG
NECETYAELK LGQELWKEGD KSFYFDTNVA YSVNQEDDWE STSPAFREAN IQGKNLIDWL
PGSTLWAGKR FYQRHDVHMI DFYYWDISGP GAGLENVDLG FGKLSLAATR NSESGGSYTF
SSDDTKKYAA KTANDVFDIR LAGLETNPGG VLELGVDYGR ANPQDDYRLE DGASKDGWMW
TGEHTQSIWG GFNKFVVQYA TDAMTSWNSG HSQGTSIDNN GSMIRVLDHG AMDFNDDWGL
MYVAMYQELD LDSKNGSTWY TVGVRPMYKW TPIMSTQLEI GYDNVKSQRT SENNNQYKIT
LAQQWQAGNS VWSRPAIRIF ATYAKWDENW GYSNTSGLQT KDSSGSGAFT SSRGDDSEVT
FGAQMEVWW
