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LAMB_SALTI
ID   LAMB_SALTI              Reviewed;         452 AA.
AC   Q8Z1T9;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Maltoporin {ECO:0000255|HAMAP-Rule:MF_01301};
DE   AltName: Full=Maltose-inducible porin {ECO:0000255|HAMAP-Rule:MF_01301};
DE   Flags: Precursor;
GN   Name=lamB {ECO:0000255|HAMAP-Rule:MF_01301};
GN   OrderedLocusNames=STY4427, t4137;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Involved in the transport of maltose and maltodextrins.
CC       {ECO:0000255|HAMAP-Rule:MF_01301}.
CC   -!- SUBUNIT: Homotrimer formed of three 18-stranded antiparallel beta-
CC       barrels, containing three independent channels. {ECO:0000255|HAMAP-
CC       Rule:MF_01301}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01301}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01301}.
CC   -!- INDUCTION: By maltose. {ECO:0000255|HAMAP-Rule:MF_01301}.
CC   -!- SIMILARITY: Belongs to the porin LamB (TC 1.B.3) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01301}.
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DR   EMBL; AL513382; CAD09215.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71601.1; -; Genomic_DNA.
DR   RefSeq; NP_458529.1; NC_003198.1.
DR   RefSeq; WP_000973678.1; NZ_WSUR01000027.1.
DR   AlphaFoldDB; Q8Z1T9; -.
DR   SMR; Q8Z1T9; -.
DR   STRING; 220341.16505219; -.
DR   EnsemblBacteria; AAO71601; AAO71601; t4137.
DR   KEGG; stt:t4137; -.
DR   KEGG; sty:STY4427; -.
DR   PATRIC; fig|220341.7.peg.4527; -.
DR   eggNOG; COG4580; Bacteria.
DR   HOGENOM; CLU_032473_4_1_6; -.
DR   OMA; DYGRANA; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0042958; F:maltodextrin transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015481; F:maltose transporting porin activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   CDD; cd01346; Maltoporin-like; 1.
DR   Gene3D; 2.40.170.10; -; 1.
DR   HAMAP; MF_01301; LamB; 1.
DR   InterPro; IPR023738; Maltoporin.
DR   InterPro; IPR003192; Porin_LamB.
DR   InterPro; IPR036998; Porin_LamB_sf.
DR   Pfam; PF02264; LamB; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Ion transport; Membrane; Porin;
KW   Signal; Sugar transport; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   CHAIN           26..452
FT                   /note="Maltoporin"
FT                   /id="PRO_0000025179"
FT   TOPO_DOM        26
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        27..35
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        36..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        65..78
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        79..80
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        81..93
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        94..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        105..115
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        116..122
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        123..130
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        131..148
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        149..159
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        160..161
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        162..173
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        174..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        192..205
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        206..209
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        210..222
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        223..234
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        235..248
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        249..250
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        251..263
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        264..300
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        301..315
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        316..317
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        318..333
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        334..336
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        337..351
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        352..353
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        354..369
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        370..372
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        373..388
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        389..395
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        396..410
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        411..436
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        437..451
FT                   /note="Beta stranded"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        452
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250"
FT   SITE            31
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            66
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            99
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            143
FT                   /note="Important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            252
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            393
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   SITE            451
FT                   /note="Greasy slide, important in sugar transport"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01301"
FT   DISULFID        47..63
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   452 AA;  50588 MW;  C4BFB8CA1218C2C2 CRC64;
     MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQV TGAQSKYRLG
     NECETYAELK LGQEVWKEGD KSFYFDTNVA YSVNQQNDWE STDPAFREAN VQGKNLIEWL
     PGSTIWAGKR FYQRHDVHMI DFYYWDISGP GAGIENIDLG FGKLSLAATR STEAGGSYTF
     SSQNIYDEVK DTANDVFDVR LAGLQTNPDG VLELGVDYGR ANTTDGYKLA DGASKDGWMF
     TAEHTQSMLK GYNKFVVQYA TDAMTTQGKG QARGSDGSSS FTEELPDGTK INYANKVINN
     NGDMWRILDH GAISLGDKWD LMYVGMYQNI DWDNNLGTEW WTVGVRPMYK WTPIMSTLLE
     VGYDNVKSQQ TGDRNNQYKI TLAQQWQAGD SIWSRPAIRI FATYAKWDEK WGYIKDGDNI
     SRYAAATNSG ISTNSRGDSD EWTFGAQMEI WW
 
 
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