LAMP5_RAT
ID LAMP5_RAT Reviewed; 280 AA.
AC Q5PPI4;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Lysosome-associated membrane glycoprotein 5;
DE AltName: Full=Brain and dendritic cell-associated LAMP;
DE AltName: Full=Brain-associated LAMP-like protein;
DE Short=BAD-LAMP;
DE AltName: Full=Lysosome-associated membrane protein 5;
DE Short=LAMP-5;
DE Flags: Precursor;
GN Name=Lamp5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in short-term synaptic plasticity in a subset of
CC GABAergic neurons in the brain. {ECO:0000250|UniProtKB:Q9D387}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC {ECO:0000250|UniProtKB:Q9D387}. Cell membrane
CC {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC {ECO:0000250|UniProtKB:Q9D387}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q9D387}. Cytoplasmic vesicle, secretory vesicle,
CC synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Cell
CC projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC Early endosome membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Recycling
CC endosome {ECO:0000250|UniProtKB:Q9D387}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UJQ1};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC Endosome membrane {ECO:0000250|UniProtKB:Q9UJQ1}; Single-pass type I
CC membrane protein {ECO:0000250|UniProtKB:Q9D387}. Note=Recycles from the
CC vesicles of the endocytic recycling compartment (ERC) to the plasma
CC membrane (By similarity). Colocalizes with UNC93B1 in large endosomal
CC intracellular vesicles (By similarity). Accumulates in the endoplasmic
CC reticulum-Golgi intermediate compartment (ERGIC) before its
CC disappearance upon activation by CpG dinucleotides (By similarity).
CC Associates with cortical membranes (By similarity). Localizes mostly in
CC cytoplasmic vesicles of neuronal cell body. Localizes to synaptic
CC vesicles in a subset of GABAergic neurons (By similarity).
CC {ECO:0000250|UniProtKB:Q9D387, ECO:0000250|UniProtKB:Q9UJQ1}.
CC -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9D387}.
CC -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000305}.
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DR EMBL; CH473949; EDL80298.1; -; Genomic_DNA.
DR EMBL; BC087680; AAH87680.1; -; mRNA.
DR RefSeq; NP_001014205.1; NM_001014183.1.
DR RefSeq; XP_017447400.1; XM_017591911.1.
DR AlphaFoldDB; Q5PPI4; -.
DR SMR; Q5PPI4; -.
DR STRING; 10116.ENSRNOP00000007274; -.
DR GlyGen; Q5PPI4; 4 sites.
DR PaxDb; Q5PPI4; -.
DR PRIDE; Q5PPI4; -.
DR Ensembl; ENSRNOT00000007274; ENSRNOP00000007274; ENSRNOG00000005457.
DR GeneID; 362220; -.
DR KEGG; rno:362220; -.
DR UCSC; RGD:1306991; rat.
DR CTD; 24141; -.
DR RGD; 1306991; Lamp5.
DR eggNOG; KOG4818; Eukaryota.
DR GeneTree; ENSGT00950000182899; -.
DR HOGENOM; CLU_090529_0_0_1; -.
DR InParanoid; Q5PPI4; -.
DR OMA; WKNNAYI; -.
DR OrthoDB; 1377400at2759; -.
DR PhylomeDB; Q5PPI4; -.
DR TreeFam; TF330776; -.
DR PRO; PR:Q5PPI4; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Proteomes; UP000234681; Chromosome 3.
DR Bgee; ENSRNOG00000005457; Expressed in frontal cortex and 2 other tissues.
DR Genevisible; Q5PPI4; RN.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
DR GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR GO; GO:0032584; C:growth cone membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISO:RGD.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR PANTHER; PTHR11506; PTHR11506; 1.
DR Pfam; PF01299; Lamp; 1.
DR PROSITE; PS00310; LAMP_1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cytoplasmic vesicle; Endosome;
KW Glycoprotein; Membrane; Reference proteome; Signal; Synapse; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..280
FT /note="Lysosome-associated membrane glycoprotein 5"
FT /id="PRO_0000360414"
FT TOPO_DOM 30..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 280 AA; 31505 MW; 555111CD85C8A8FA CRC64;
MDLRGRALLG GDRLRILLMF FHAMAQTVAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA
EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGRCG HNESELQVFW VDRAYTLKML
FVKESHNTSK GLEATWKLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGMSY
ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI
LGLILGLVIV ITLVIYHIHH KMTANQVQIP RDRSQYKHMG
