ID   LAMP5_XENTR             Reviewed;         276 AA.
AC   A4IGL3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Lysosome-associated membrane glycoprotein 5;
DE   AltName: Full=Lysosome-associated membrane protein 5;
DE            Short=LAMP-5;
DE   Flags: Precursor;
GN   Name=lamp5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in short-term synaptic plasticity in a subset of
CC       GABAergic neurons in the brain. {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9D387}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9D387}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:Q9D387}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q9D387}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC       type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Cell
CC       projection, growth cone membrane {ECO:0000250|UniProtKB:Q9D387};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC       Early endosome membrane {ECO:0000250|UniProtKB:Q9D387}; Single-pass
CC       type I membrane protein {ECO:0000250|UniProtKB:Q9D387}. Recycling
CC       endosome {ECO:0000250|UniProtKB:Q9D387}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000250|UniProtKB:Q9UJQ1};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q9UJQ1}; Single-pass type I
CC       membrane protein {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9D387}.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000305}.
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DR   EMBL; BC135151; AAI35152.1; -; mRNA.
DR   RefSeq; NP_001090781.1; NM_001097312.1.
DR   RefSeq; XP_012817987.1; XM_012962533.2.
DR   AlphaFoldDB; A4IGL3; -.
DR   SMR; A4IGL3; -.
DR   STRING; 8364.ENSXETP00000033005; -.
DR   PaxDb; A4IGL3; -.
DR   DNASU; 100037871; -.
DR   Ensembl; ENSXETT00000033005; ENSXETP00000033005; ENSXETG00000015086.
DR   GeneID; 100037871; -.
DR   KEGG; xtr:100037871; -.
DR   CTD; 24141; -.
DR   Xenbase; XB-GENE-941198; lamp5.
DR   eggNOG; KOG4818; Eukaryota.
DR   HOGENOM; CLU_090529_0_0_1; -.
DR   InParanoid; A4IGL3; -.
DR   OMA; WKNNAYI; -.
DR   OrthoDB; 1377400at2759; -.
DR   PhylomeDB; A4IGL3; -.
DR   TreeFam; TF330776; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015086; Expressed in brain and 1 other tissue.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; ISS:UniProtKB.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; ISS:UniProtKB.
DR   GO; GO:0032584; C:growth cone membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   PANTHER; PTHR11506; PTHR11506; 1.
DR   Pfam; PF01299; Lamp; 1.
DR   PROSITE; PS00310; LAMP_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasmic vesicle; Endosome;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Synapse; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..276
FT                   /note="Lysosome-associated membrane glycoprotein 5"
FT                   /id="PRO_0000360416"
FT   TOPO_DOM        28..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        253..276
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   276 AA;  31485 MW;  8D0D7B4E01A55AE4 CRC64;
     MDYRACTSAL RMPVLLLLLC TFSCNLAEQE VENLSGLSSN PDKNIFAIRE NGTTCLMAEF
     SARILVPYEV PSSNEVDWDL EEASIQLPRD TEIRGKCWNN ESELHLSWLD KAYTLKLFFS
     KEGQDASKSR SWKMSKIQFL YDPSEHTIFK SGARPGRHTA NSHHLSLMVT PAGMSYECEA
     TQRISLTSTD HQKIVVLYLS EVHLQPFDIK SDFVYSEEYK CPTDQRKQLE ETLPLILGLT
     LGVAILIIVA VYHIHHKMTA NQVQIPRDRS LYKHMG