ID   LAMR_PETMA              Reviewed;         119 AA.
AC   P33577;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Lamprin 1.8-10;
DE   AltName: Full=Cartilage matrix protein;
DE   Flags: Precursor;
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 20-44.
RC   TISSUE=Cartilage;
RX   PubMed=7678258; DOI=10.1016/s0021-9258(18)54095-3;
RA   Robson P., Wright G.M., Sitarz E., Maiti A., Rawat M., Youson J.H.,
RA   Keeley F.W.;
RT   "Characterization of lamprin, an unusual matrix protein from lamprey
RT   cartilage. Implications for evolution, structure, and assembly of elastin
RT   and other fibrillar proteins.";
RL   J. Biol. Chem. 268:1440-1447(1993).
CC   -!- FUNCTION: Self-aggregating protein that is part of the soluble form of
CC       lamprin.
CC   -!- SUBUNIT: The polymeric lamprin chains self-aggregate to form fibers and
CC       have secondary structures particularly rich in beta-sheets and in beta-
CC       turns.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
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DR   EMBL; L05926; AAA49270.1; -; mRNA.
DR   PIR; B45051; B45051.
DR   AlphaFoldDB; P33577; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR009437; Lamprin.
DR   Pfam; PF06403; Lamprin; 1.
DR   PIRSF; PIRSF002264; Lamprin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Extracellular matrix; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:7678258"
FT   CHAIN           20..119
FT                   /note="Lamprin 1.8-10"
FT                   /id="PRO_0000021577"
FT   REPEAT          41..45
FT                   /note="1"
FT   REPEAT          46..50
FT                   /note="2"
FT   REPEAT          51..55
FT                   /note="3"
FT   REPEAT          56..60
FT                   /note="4"
FT   REPEAT          61..65
FT                   /note="5"
FT   REPEAT          66..70
FT                   /note="6"
FT   REPEAT          86..90
FT                   /note="7"
FT   REGION          41..90
FT                   /note="7 X 5 AA approximate repeats"
SQ   SEQUENCE   119 AA;  11329 MW;  4EB476FACB7591B8 CRC64;
     MAATMQALLV IALLHLATAT PVVTKHKVST FSTGFLGHPV GGLGYGGLGY GGLGYGGLGV
     AGLGYGGLGY PGAALGGAYT HHAALGGLGY PLGIGAGVVA PHVVNSKIAA PLAPVVAAI