ID   LAN91_MICS0             Reviewed;          24 AA.
AC   P85065;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Lantibiotic 107891;
OS   Microbispora sp. (strain 107891).
OC   Bacteria; Actinobacteria; Streptosporangiales; Streptosporangiaceae;
OC   Microbispora.
OX   NCBI_TaxID=415003;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, DEHYDRATION AT THR-2 AND SER-5, HYDROXYLATION
RP   AT PRO-14, AND MASS SPECTROMETRY.
RA   Lazzarini A., Gastaldo L., Candiani G., Ciciliato I., Losi D.,
RA   Marinelli F., Selva E., Parenti F.;
RT   "Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable
RT   salts and compositions, and use thereof.";
RL   Patent number WO2005014628, 17-FEB-2005.
CC   -!- FUNCTION: Lanthionine-containing peptide antibiotic (lantibiotic)
CC       active on Gram-positive bacteria. The bactericidal activity of
CC       lantibiotics is based on depolarization of energized bacterial
CC       cytoplasmic membranes, initiated by the formation of aqueous
CC       transmembrane pores. {ECO:0000269|Ref.1, ECO:0000305}.
CC   -!- PTM: Maturation of lantibiotics involves the enzymatic conversion of
CC       Thr, and Ser into dehydrated AA and the formation of thioether bonds
CC       with cysteine. The C-terminal lanthionine undergoes decarboxylation.
CC       This is followed by membrane translocation and cleavage of the modified
CC       precursor. {ECO:0000305}.
CC   -!- PTM: Occurs in 2 forms, A1 contains 3,4-dihydroxyproline at Pro-14, A2
CC       contains 4-hydroxyproline at Pro-14. The patent report does not provide
CC       the stereochemistry of the modified prolines.
CC   -!- PTM: The patent report does not describe whether the 2,3-
CC       didehydrobutyrine is the E- or Z-isomer. In several diagrams it is
CC       shown as the E-isomer.
CC   -!- MASS SPECTROMETRY: Mass=1124; Method=Electrospray; Note=The measured
CC       mass is that of form A1.; Evidence={ECO:0000269|Ref.1};
CC   -!- MASS SPECTROMETRY: Mass=1116; Method=Electrospray; Note=The measured
CC       mass is that of form A2.; Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the type A lantibiotic family. {ECO:0000255}.
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DR   PDB; 2MH5; NMR; -; A=1-23.
DR   PDBsum; 2MH5; -.
DR   AlphaFoldDB; P85065; -.
DR   SMR; P85065; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Bacteriocin; D-amino acid;
KW   Direct protein sequencing; Hydroxylation; Lantibiotic; Thioether bond.
FT   PEPTIDE         1..24
FT                   /note="Lantibiotic 107891"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000271410"
FT   MOD_RES         2
FT                   /note="(E)-2,3-didehydrobutyrine"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         4
FT                   /note="6'-chlorotryptophan"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         5
FT                   /note="2,3-didehydroalanine (Ser)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         14
FT                   /note="3,4-dihydroxyproline; in form A1"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         14
FT                   /note="4-hydroxyproline; in form A2"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CROSSLNK        3..7
FT                   /note="Lanthionine (Ser-Cys)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CROSSLNK        8..11
FT                   /note="Beta-methyllanthionine (Thr-Cys)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CROSSLNK        13..20
FT                   /note="Lanthionine (Ser-Cys)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CROSSLNK        18..23
FT                   /note="Lanthionine (Ser-Cys)"
FT                   /evidence="ECO:0000269|Ref.1"
FT   CROSSLNK        21..24
FT                   /note="S-(2-aminovinyl)-D-cysteine (Ser-Cys)"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   24 AA;  2355 MW;  143669100970B79F CRC64;
     VTSWSLCTPG CTSPGGGSNC SFCC