ID   LANA_STRSL              Reviewed;          48 AA.
AC   P36500;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Lantibiotic salivaricin-A;
DE   Flags: Precursor;
GN   Name=salA;
OS   Streptococcus salivarius.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 27-42.
RC   STRAIN=20P3;
RX   PubMed=8357242; DOI=10.1128/aem.59.7.2014-2021.1993;
RA   Ross K.F., Ronson C.W., Tagg J.R.;
RT   "Isolation and characterization of the lantibiotic salivaricin A and its
RT   structural gene salA from Streptococcus salivarius 20P3.";
RL   Appl. Environ. Microbiol. 59:2014-2021(1993).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RC   STRAIN=20P3;
RA   Upton M., Tagg J.R., Jenkinson H.F.;
RT   "Salivaricin A gene cluster from Streptococcus salivarius.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lanthionine-containing peptide antibiotic (lantibiotic)
CC       active on Gram-positive bacteria. The bactericidal activity of
CC       lantibiotics is based on depolarization of energized bacterial
CC       cytoplasmic membranes, initiated by the formation of aqueous
CC       transmembrane pores.
CC   -!- PTM: Maturation of lantibiotics involves the enzymatic conversion of
CC       Thr, and Ser into dehydrated AA and the formation of thioether bonds
CC       with cysteine. This is followed by membrane translocation and cleavage
CC       of the modified precursor.
CC   -!- SIMILARITY: Belongs to the type A lantibiotic family. {ECO:0000305}.
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DR   EMBL; AY005472; AAA02867.2; -; Genomic_DNA.
DR   AlphaFoldDB; P36500; -.
DR   SMR; P36500; -.
DR   TCDB; 1.C.21.1.4; the lacticin 481 (lacticin 481) family.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR007682; Lantibiotic_typ-A_Lactobact.
DR   Pfam; PF04604; L_biotic_typeA; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Lantibiotic; Thioether bond.
FT   PROPEP          1..26
FT                   /evidence="ECO:0000269|PubMed:8357242"
FT                   /id="PRO_0000017132"
FT   PEPTIDE         27..48
FT                   /note="Lantibiotic salivaricin-A"
FT                   /id="PRO_0000017133"
FT   CROSSLNK        35..40
FT                   /note="Beta-methyllanthionine (Thr-Cys)"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        37..47
FT                   /note="Beta-methyllanthionine (Thr-Cys)"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        43..48
FT                   /note="Lanthionine (Ser-Cys)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   48 AA;  5204 MW;  3AF70C1A3CFCFF79 CRC64;
     MKNSKDILNN AIEEVSEKEL MEVAGGKRGS GWIATITDDC PNSVFVCC