ID   LANB_STRP9              Reviewed;          51 AA.
AC   Q54957;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Lantibiotic streptococcin A-M49;
DE   AltName: Full=Antibacterial peptide A-M49;
DE   Flags: Precursor;
GN   Name=scnA';
GN   and
GN   Name=scnA'';
OS   Streptococcus pyogenes serotype M49.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301452;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GT9538 / Serotype M49;
RX   PubMed=7993103; DOI=10.1128/aem.60.11.4207-4209.1994;
RA   Hynes W.L., Friend V.L., Ferretti J.J.;
RT   "Duplication of the lantibiotic structural gene in M-type 49 group A
RT   streptococcus strains producing streptococcin A-M49.";
RL   Appl. Environ. Microbiol. 60:4207-4209(1994).
CC   -!- FUNCTION: Lanthionine-containing peptide antibiotic (lantibiotic)
CC       active on certain Gram-positive bacteria. The bactericidal activity of
CC       lantibiotics is based on depolarization of energized bacterial
CC       cytoplasmic membranes, initiated by the formation of aqueous
CC       transmembrane pores (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell surface
CC       {ECO:0000250}. Note=Either cell associated or in a released
CC       extracellular form. {ECO:0000250}.
CC   -!- PTM: Maturation of lantibiotics involves the enzymatic conversion of
CC       Thr, and Ser into dehydrated AA and the formation of thioether bonds
CC       with cysteine. This is followed by membrane translocation and cleavage
CC       of the modified precursor (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: There are two genes coding for lantibiotic streptococcin
CC       A-M49, their coding sequences only differ in the propeptide region.
CC   -!- SIMILARITY: Belongs to the type A lantibiotic family. {ECO:0000305}.
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DR   EMBL; L36235; AAA62362.1; -; Genomic_DNA.
DR   EMBL; L36235; AAA62361.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q54957; -.
DR   TCDB; 1.C.21.1.3; the lacticin 481 (lacticin 481) family.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR007682; Lantibiotic_typ-A_Lactobact.
DR   Pfam; PF04604; L_biotic_typeA; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriocin; Lantibiotic; Secreted;
KW   Thioether bond.
FT   PROPEP          1..25
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000017136"
FT   PEPTIDE         26..51
FT                   /note="Lantibiotic streptococcin A-M49"
FT                   /id="PRO_0000017137"
FT   MOD_RES         48
FT                   /note="2,3-didehydrobutyrine"
FT                   /evidence="ECO:0000250|UniProtKB:P36501"
FT   CROSSLNK        33..38
FT                   /note="Beta-methyllanthionine (Thr-Cys)"
FT                   /evidence="ECO:0000250|UniProtKB:P36501"
FT   CROSSLNK        35..49
FT                   /note="Lanthionine (Ser-Cys)"
FT                   /evidence="ECO:0000250|UniProtKB:P36501"
FT   CROSSLNK        42..50
FT                   /note="Beta-methyllanthionine (Thr-Cys)"
FT                   /evidence="ECO:0000250|UniProtKB:P36501"
FT   VARIANT         2
FT                   /note="T -> E (in scnA'')"
FT   VARIANT         4..5
FT                   /note="EH -> NN (in scnA'')"
FT   VARIANT         7
FT                   /note="I -> V (in scnA'')"
SQ   SEQUENCE   51 AA;  5690 MW;  F12124BA13E17FD1 CRC64;
     MTKEHEIINS IQEVSLEELD QIIGAGKNGV FKTISHECHL NTWAFLATCC S