LANC3_HUMAN
ID LANC3_HUMAN Reviewed; 420 AA.
AC Q6ZV70; A6NHE3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=LanC-like protein 3;
GN Name=LANCL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZV70-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZV70-2; Sequence=VSP_024855;
CC -!- SIMILARITY: Belongs to the LanC-like protein family. {ECO:0000305}.
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DR EMBL; AK124915; BAC85993.1; -; mRNA.
DR EMBL; AL627244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093667; AAH93667.1; -; mRNA.
DR EMBL; BC093669; AAH93669.1; -; mRNA.
DR CCDS; CCDS14240.1; -. [Q6ZV70-2]
DR CCDS; CCDS55398.1; -. [Q6ZV70-1]
DR RefSeq; NP_001163802.1; NM_001170331.1. [Q6ZV70-1]
DR RefSeq; NP_940913.1; NM_198511.2. [Q6ZV70-2]
DR AlphaFoldDB; Q6ZV70; -.
DR SMR; Q6ZV70; -.
DR BioGRID; 131432; 3.
DR STRING; 9606.ENSP00000367882; -.
DR iPTMnet; Q6ZV70; -.
DR PhosphoSitePlus; Q6ZV70; -.
DR BioMuta; LANCL3; -.
DR DMDM; 146324960; -.
DR MassIVE; Q6ZV70; -.
DR MaxQB; Q6ZV70; -.
DR PaxDb; Q6ZV70; -.
DR PeptideAtlas; Q6ZV70; -.
DR PRIDE; Q6ZV70; -.
DR ProteomicsDB; 68395; -. [Q6ZV70-1]
DR ProteomicsDB; 68396; -. [Q6ZV70-2]
DR Antibodypedia; 585; 85 antibodies from 18 providers.
DR DNASU; 347404; -.
DR Ensembl; ENST00000378619.4; ENSP00000367882.4; ENSG00000147036.12. [Q6ZV70-1]
DR Ensembl; ENST00000378621.7; ENSP00000367885.3; ENSG00000147036.12. [Q6ZV70-2]
DR Ensembl; ENST00000614025.4; ENSP00000479231.1; ENSG00000147036.12. [Q6ZV70-2]
DR GeneID; 347404; -.
DR KEGG; hsa:347404; -.
DR MANE-Select; ENST00000378619.4; ENSP00000367882.4; NM_001170331.2; NP_001163802.1.
DR UCSC; uc004ddp.3; human. [Q6ZV70-1]
DR CTD; 347404; -.
DR GeneCards; LANCL3; -.
DR HGNC; HGNC:24767; LANCL3.
DR HPA; ENSG00000147036; Tissue enriched (brain).
DR neXtProt; NX_Q6ZV70; -.
DR OpenTargets; ENSG00000147036; -.
DR PharmGKB; PA134879796; -.
DR VEuPathDB; HostDB:ENSG00000147036; -.
DR eggNOG; KOG2787; Eukaryota.
DR GeneTree; ENSGT00530000063186; -.
DR HOGENOM; CLU_036244_0_1_1; -.
DR InParanoid; Q6ZV70; -.
DR OMA; CTRAEEW; -.
DR OrthoDB; 681208at2759; -.
DR PhylomeDB; Q6ZV70; -.
DR TreeFam; TF300068; -.
DR PathwayCommons; Q6ZV70; -.
DR BioGRID-ORCS; 347404; 22 hits in 705 CRISPR screens.
DR GenomeRNAi; 347404; -.
DR Pharos; Q6ZV70; Tdark.
DR PRO; PR:Q6ZV70; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6ZV70; protein.
DR Bgee; ENSG00000147036; Expressed in dorsal root ganglion and 87 other tissues.
DR Genevisible; Q6ZV70; HS.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR007822; LANC-like.
DR InterPro; IPR020464; LanC-like_prot_euk.
DR Pfam; PF05147; LANC_like; 1.
DR PRINTS; PR01951; LANCEUKARYTE.
DR PRINTS; PR01950; LANCSUPER.
DR SMART; SM01260; LANC_like; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..420
FT /note="LanC-like protein 3"
FT /id="PRO_0000285251"
FT VAR_SEQ 368..420
FT /note="RFAQFLFTEEFKAGSRVLESIYSLYEGFSGTVCFLIDLLQPNQAEFPLFSVF
FT V -> SSFPVNLIKMEHLLYTRQHCF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_024855"
SQ SEQUENCE 420 AA; 46319 MW; EB5A966DE8784468 CRC64;
MDTKRCFANR FDDYQGSLLA GQCEEAVAPL VTATIERILQ ELPPLGGGAE ARGATAGASA
CQGGLYGGVA GVAYMLYHVS QSPLFATARE RYLRSAKRLI DACARAEEWG EPDADTRAAF
LLGGAGVYAV ATLVYHALGR SDYVQPLGKF RALCAVCAPV SFLECGSDEL FVGRAGYLCA
ALVLKQKLAQ EVLTPAQIKS ICQAILDSGK QYAIKKRKPF PLMYSYYGTE YLGAAHGLSS
ILQMLLSYHE HLKPSDRELV WQSVDFLMEQ EQNCNWPPEL GETIERENEL VHWCHGAPGI
AYLFAKAYLV SKKPQYLDTC IRCGELTWQK GLLKKGPGIC HGVAGSAYVF LLLYRLTGNS
KYIYRAQRFA QFLFTEEFKA GSRVLESIYS LYEGFSGTVC FLIDLLQPNQ AEFPLFSVFV
