LANC3_MOUSE
ID LANC3_MOUSE Reviewed; 420 AA.
AC Q8CD19; A2AFA5; Q14BF1; Q8BRA2; Q8BRN8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=LanC-like protein 3;
GN Name=Lancl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CD19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CD19-2; Sequence=VSP_024856;
CC -!- SIMILARITY: Belongs to the LanC-like protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32282.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK045254; BAC32282.1; ALT_FRAME; mRNA.
DR EMBL; AK031623; BAC27485.1; -; mRNA.
DR EMBL; AK043841; BAC31676.1; -; mRNA.
DR EMBL; AL672060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115944; AAI15945.1; -; mRNA.
DR CCDS; CCDS30007.1; -. [Q8CD19-1]
DR RefSeq; NP_775590.2; NM_173414.3. [Q8CD19-1]
DR AlphaFoldDB; Q8CD19; -.
DR SMR; Q8CD19; -.
DR STRING; 10090.ENSMUSP00000064516; -.
DR PhosphoSitePlus; Q8CD19; -.
DR EPD; Q8CD19; -.
DR MaxQB; Q8CD19; -.
DR PaxDb; Q8CD19; -.
DR PRIDE; Q8CD19; -.
DR ProteomicsDB; 264914; -. [Q8CD19-1]
DR ProteomicsDB; 264915; -. [Q8CD19-2]
DR Antibodypedia; 585; 85 antibodies from 18 providers.
DR DNASU; 236285; -.
DR Ensembl; ENSMUST00000069763; ENSMUSP00000064516; ENSMUSG00000047344. [Q8CD19-1]
DR GeneID; 236285; -.
DR KEGG; mmu:236285; -.
DR UCSC; uc009spo.1; mouse. [Q8CD19-1]
DR CTD; 347404; -.
DR MGI; MGI:2443335; Lancl3.
DR VEuPathDB; HostDB:ENSMUSG00000047344; -.
DR eggNOG; KOG2787; Eukaryota.
DR GeneTree; ENSGT00530000063186; -.
DR HOGENOM; CLU_036244_1_0_1; -.
DR InParanoid; Q8CD19; -.
DR OMA; CTRAEEW; -.
DR OrthoDB; 681208at2759; -.
DR PhylomeDB; Q8CD19; -.
DR TreeFam; TF300068; -.
DR BioGRID-ORCS; 236285; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8CD19; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8CD19; protein.
DR Bgee; ENSMUSG00000047344; Expressed in lumbar dorsal root ganglion and 93 other tissues.
DR Genevisible; Q8CD19; MM.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR007822; LANC-like.
DR InterPro; IPR020464; LanC-like_prot_euk.
DR Pfam; PF05147; LANC_like; 1.
DR PRINTS; PR01951; LANCEUKARYTE.
DR PRINTS; PR01950; LANCSUPER.
DR SMART; SM01260; LANC_like; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..420
FT /note="LanC-like protein 3"
FT /id="PRO_0000285252"
FT VAR_SEQ 1..243
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024856"
FT CONFLICT 261
FT /note="W -> R (in Ref. 1; BAC27485)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 46475 MW; 7DDA13EBCD7BD079 CRC64;
MDTKRCFANR FDDYQGSLLA GQCEEAVAPL VTSTIERILQ ELPPLGGGAE ARGATGAGSS
CQGGLYSGVA GVAYMLYHVS QSPLFAAARE RYLRFAKRLI DACLRAEEWG ETDADTRAAF
LLGGAGVYAV ATLVYHALGR PDYVQPLGKF RALCAVCAPV SFLDCGSDEL FVGRAGYLCA
ALVLKQKLAQ EVLTPTQIKA ICQAILDSGK QYALKKRKPF PLMYSYYGTE YLGAAHGLSS
ILQMLLSYQE HLKPSDRELV WQSVDFLMEQ EQNCNWPPEL GETIERENEL VHWCHGAPGI
AYLFAKAYLI SKKPQYLDTC IRCGELTWQK GLLKKGPGIC HGVAGSAYVF LLLYRLTGNS
KYIYRAQRFA QFLFTEEFKS GSRVLESIYS LYEGFSGTVC FLIDLLQPNQ AEFPLFSVFV
