LAP1_DROME
ID LAP1_DROME Reviewed; 849 AA.
AC Q9V780;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein lap1;
GN Name=Lap1 {ECO:0000312|EMBL:AAF58179.1}; ORFNames=CG10255;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF58179.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF58179.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAR96157.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAR96157.1}; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May have a role in assembling adherens junctions.
CC {ECO:0000250|UniProtKB:O61967}.
CC -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC {ECO:0000305}.
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DR EMBL; AE013599; AAF58179.1; -; Genomic_DNA.
DR EMBL; BT011365; AAR96157.1; -; mRNA.
DR RefSeq; NP_001188938.1; NM_001202009.2.
DR RefSeq; NP_611007.1; NM_137163.5.
DR AlphaFoldDB; Q9V780; -.
DR SMR; Q9V780; -.
DR BioGRID; 62412; 6.
DR IntAct; Q9V780; 2.
DR STRING; 7227.FBpp0086538; -.
DR PaxDb; Q9V780; -.
DR PRIDE; Q9V780; -.
DR DNASU; 36670; -.
DR EnsemblMetazoa; FBtr0087407; FBpp0086538; FBgn0033984.
DR EnsemblMetazoa; FBtr0303759; FBpp0292771; FBgn0033984.
DR GeneID; 36670; -.
DR KEGG; dme:Dmel_CG10255; -.
DR UCSC; CG10255-RA; d. melanogaster.
DR CTD; 36670; -.
DR FlyBase; FBgn0033984; Lap1.
DR VEuPathDB; VectorBase:FBgn0033984; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_336254_0_0_1; -.
DR InParanoid; Q9V780; -.
DR OMA; THIYGVY; -.
DR OrthoDB; 992188at2759; -.
DR PhylomeDB; Q9V780; -.
DR SignaLink; Q9V780; -.
DR BioGRID-ORCS; 36670; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36670; -.
DR PRO; PR:Q9V780; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033984; Expressed in brain and 25 other tissues.
DR ExpressionAtlas; Q9V780; baseline and differential.
DR Genevisible; Q9V780; DM.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS51450; LRR; 13.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..849
FT /note="Protein lap1"
FT /id="PRO_0000188306"
FT REPEAT 18..39
FT /note="LRR 1"
FT REPEAT 41..62
FT /note="LRR 2"
FT REPEAT 64..85
FT /note="LRR 3"
FT REPEAT 87..108
FT /note="LRR 4"
FT REPEAT 110..131
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 133..155
FT /note="LRR 6"
FT REPEAT 156..177
FT /note="LRR 7"
FT REPEAT 179..200
FT /note="LRR 8"
FT REPEAT 202..224
FT /note="LRR 9"
FT REPEAT 225..246
FT /note="LRR 10"
FT REPEAT 248..269
FT /note="LRR 11"
FT REPEAT 271..292
FT /note="LRR 12"
FT REPEAT 294..315
FT /note="LRR 13"
FT REPEAT 317..338
FT /note="LRR 14"
FT REPEAT 340..362
FT /note="LRR 15"
FT REPEAT 363..384
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 386..407
FT /note="LRR 17"
FT DOMAIN 770..849
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 716..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 96148 MW; C86DD96C242080E2 CRC64;
MPLLSKCFPC FKFKREEVID KLDYSNTPLT DFPEVWQHER TLEELYLSTT RLQALPPQLF
YCQGLRVLHV NSNNLESIPQ AIGSLRQLQH LDLNRNLIVN VPEEIKSCKH LTHLDLSCNS
LQRLPDAITS LISLQELLLN ETYLEFLPAN FGRLVNLRIL ELRLNNLMTL PKSMVRLINL
QRLDIGGNEF TELPEVVGEL KSLRELWIDF NQIRRVSANI GKLRDLQHFE ANGNLLDTLP
SELSNWRNVE VLSICSNSLE AFPFSVGMLK SLVTFKCESN GLTELPDSIS YLEQLEELVL
SHNKLIRLPS TIGMLRSLRF LFADDNQLRQ LPDELCSCQQ LSVLSVANNQ LSALPQNIGN
LSKMKVLNVV NNYINALPVS MLNLVNLTSM WLSDNQSQPL VPLQYLDAST KTQLTCFMLP
QVTFKMNSIQ AQQQAQEQYE FVYANQQQPH ASPSRRICFA EEATILSNAK AQPAPNYPSF
VAAPPTPTPD QMAGSVRLMR SPTPYPKELR QMSKYVRQAQ AATSSANASE VREARVVTNG
QIHCDSNNAN QDVVDQATTS AIYGIAPETT HIYGVYQQPQ QMAHPVPTQE YYGLPLVNYE
AHYQQLYVEA NTPLPTTHLN GDQDYELQPL QQQPMQQQAL PTPRLEPPPY HIARVYTKKT
PEDLNLYESM RQRKQQQQLQ EQTIYQDALN SNSNFKTTAI GAQDVEESVD QLDYQNNISN
NLEPNPEEED QELDDTMSQH SLNSTATNNT SKASHKKSTW IFGVHKNPTV KQVTLKWENS
IGFDIAELLN QVGIFVSSIT PNTNAARLLN LNDKLLEIDG YDLTNANLSD AKRVLLNCGT
VMNIMLSRK
