ID   LAP4A_BOVIN             Reviewed;         233 AA.
AC   Q6QRN8;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Lysosomal-associated transmembrane protein 4A;
GN   Name=LAPTM4A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Shin M.L., Cui X.S., Park S.Y., Kim E.Y., Park S.P., Lee W.J., Hwang K.C.,
RA   Kim N.H.;
RT   "Analysis of gene expression in the bovine blastocyst or hatched blastocyst
RT   in vitro using ACP method.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function in the transport of nucleosides and/or
CC       nucleoside derivatives between the cytosol and the lumen of an
CC       intracellular membrane-bound compartment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=May reside in an intracellular
CC       membrane-bound compartment. {ECO:0000305}.
CC   -!- DOMAIN: The C-terminal domain is necessary for retention within
CC       intracellular membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AY528247; AAS20595.1; -; mRNA.
DR   EMBL; BC105519; AAI05520.1; -; mRNA.
DR   RefSeq; NP_991368.1; NM_205799.1.
DR   AlphaFoldDB; Q6QRN8; -.
DR   STRING; 9913.ENSBTAP00000027837; -.
DR   PaxDb; Q6QRN8; -.
DR   Ensembl; ENSBTAT00000027837; ENSBTAP00000027837; ENSBTAG00000020894.
DR   GeneID; 404135; -.
DR   KEGG; bta:404135; -.
DR   CTD; 9741; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020894; -.
DR   VGNC; VGNC:30787; LAPTM4A.
DR   eggNOG; ENOG502QSAX; Eukaryota.
DR   GeneTree; ENSGT00940000153446; -.
DR   HOGENOM; CLU_059239_2_0_1; -.
DR   InParanoid; Q6QRN8; -.
DR   OMA; HPNTVPT; -.
DR   OrthoDB; 1145926at2759; -.
DR   TreeFam; TF330843; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000020894; Expressed in spermatocyte and 107 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   Pfam; PF03821; Mtp; 2.
DR   TIGRFAMs; TIGR00799; mtp; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..233
FT                   /note="Lysosomal-associated transmembrane protein 4A"
FT                   /id="PRO_0000249714"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15012"
SQ   SEQUENCE   233 AA;  26820 MW;  D6A224F96ECCF4C2 CRC64;
     MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV
     NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF
     VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFA LFIIFKAYLI
     NCVWNCYKYI NNRNMPEIAV YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY IPA