ID   LAP4A_CHICK             Reviewed;         229 AA.
AC   Q5ZML7;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Lysosomal-associated transmembrane protein 4A;
GN   Name=LAPTM4A; ORFNames=RCJMB04_1k20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May function in the transport of nucleosides and/or
CC       nucleoside derivatives between the cytosol and the lumen of an
CC       intracellular membrane-bound compartment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=May reside in an intracellular
CC       membrane-bound compartment. {ECO:0000305}.
CC   -!- DOMAIN: The C-terminal domain is necessary for retention within
CC       intracellular membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AJ719367; CAG31026.1; -; mRNA.
DR   RefSeq; NP_001026263.1; NM_001031092.1.
DR   AlphaFoldDB; Q5ZML7; -.
DR   STRING; 9031.ENSGALP00000026537; -.
DR   PaxDb; Q5ZML7; -.
DR   GeneID; 421959; -.
DR   KEGG; gga:421959; -.
DR   CTD; 9741; -.
DR   VEuPathDB; HostDB:geneid_421959; -.
DR   eggNOG; ENOG502QSAX; Eukaryota.
DR   InParanoid; Q5ZML7; -.
DR   OrthoDB; 1145926at2759; -.
DR   PhylomeDB; Q5ZML7; -.
DR   PRO; PR:Q5ZML7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   Pfam; PF03821; Mtp; 2.
DR   TIGRFAMs; TIGR00799; mtp; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..229
FT                   /note="Lysosomal-associated transmembrane protein 4A"
FT                   /id="PRO_0000249718"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   229 AA;  26274 MW;  FB3FA703DF54F29B CRC64;
     MTFKRSRDRF YSTRCCGCCH VRTGTIILGT WYMVVNLLMG ILLTVEVTHP NVVPTVNIQY
     EVIGNYYASE RMAENACVLF AISLLMFTIS AMMVYGAIAH RVGWLIPFFC YQLFDFVVSC
     LVAISSLTYL PRIKDYLDQL PDFPYKDDLL SLDSSCLLFI VLVFFALFII LKAYLINCVW
     NCYKYISNRN LPEIAVYPAF EAPPQYVLPT YEMAVKMPEK EPSPSYIPA