ID   LAP4A_MACFA             Reviewed;         233 AA.
AC   Q4R4I5;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Lysosomal-associated transmembrane protein 4A;
GN   Name=LAPTM4A; ORFNames=QtrA-13112;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function in the transport of nucleosides and/or
CC       nucleoside derivatives between the cytosol and the lumen of an
CC       intracellular membrane-bound compartment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=May reside in an intracellular
CC       membrane-bound compartment. {ECO:0000305}.
CC   -!- DOMAIN: The C-terminal domain is necessary for retention within
CC       intracellular membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AB169909; BAE01990.1; -; mRNA.
DR   RefSeq; NP_001272251.1; NM_001285322.1.
DR   AlphaFoldDB; Q4R4I5; -.
DR   STRING; 9541.XP_005576535.1; -.
DR   Ensembl; ENSMFAT00000094749; ENSMFAP00000057898; ENSMFAG00000036772.
DR   GeneID; 101867509; -.
DR   CTD; 9741; -.
DR   VEuPathDB; HostDB:ENSMFAG00000036772; -.
DR   eggNOG; ENOG502QSAX; Eukaryota.
DR   GeneTree; ENSGT00940000153446; -.
DR   OMA; HPNTVPT; -.
DR   OrthoDB; 1145926at2759; -.
DR   Proteomes; UP000233100; Chromosome 13.
DR   Bgee; ENSMFAG00000036772; Expressed in pituitary gland and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   Pfam; PF03821; Mtp; 2.
DR   TIGRFAMs; TIGR00799; mtp; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..233
FT                   /note="Lysosomal-associated transmembrane protein 4A"
FT                   /id="PRO_0000249715"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15012"
SQ   SEQUENCE   233 AA;  26788 MW;  A06523896ECCE1D6 CRC64;
     MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV
     NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF
     VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFA LFIIFKAYLI
     NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPA