LAP4A_MOUSE
ID LAP4A_MOUSE Reviewed; 233 AA.
AC Q60961;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Lysosomal-associated transmembrane protein 4A;
DE AltName: Full=Golgi 4-transmembrane-spanning transporter;
DE AltName: Full=Mouse transporter protein;
DE Short=MTP;
GN Name=Laptm4a; Synonyms=Mtrp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=DBA/2J; TISSUE=Brain, and Leukemia;
RX PubMed=8621662; DOI=10.1074/jbc.271.16.9801;
RA Hogue D.L., Ellison M.J., Young J.D., Cass C.E.;
RT "Identification of a novel membrane transporter associated with
RT intracellular membranes by phenotypic complementation in the yeast
RT Saccharomyces cerevisiae.";
RL J. Biol. Chem. 271:9801-9808(1996).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May function in the transport of nucleosides and/or
CC nucleoside derivatives between the cytosol and the lumen of an
CC intracellular membrane-bound compartment.
CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}. Note=May reside in an intracellular
CC membrane-bound compartment. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=Long;
CC IsoId=Q60961-1; Sequence=Displayed;
CC Name=Short; Synonyms=Truncated, MTP1;
CC IsoId=Q60961-2; Sequence=VSP_018821;
CC -!- DOMAIN: The C-terminal domain is necessary for retention within
CC intracellular membranes.
CC -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC {ECO:0000305}.
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DR EMBL; U34259; AAB04938.1; -; mRNA.
DR CCDS; CCDS36402.1; -. [Q60961-1]
DR AlphaFoldDB; Q60961; -.
DR SMR; Q60961; -.
DR STRING; 10090.ENSMUSP00000020909; -.
DR TCDB; 2.A.74.1.1; the 4 tms multidrug endosomal transporter (met) family.
DR iPTMnet; Q60961; -.
DR PhosphoSitePlus; Q60961; -.
DR SwissPalm; Q60961; -.
DR MaxQB; Q60961; -.
DR PaxDb; Q60961; -.
DR PeptideAtlas; Q60961; -.
DR PRIDE; Q60961; -.
DR ProteomicsDB; 264971; -. [Q60961-1]
DR ProteomicsDB; 264972; -. [Q60961-2]
DR MGI; MGI:108017; Laptm4a.
DR eggNOG; ENOG502QSAX; Eukaryota.
DR InParanoid; Q60961; -.
DR PhylomeDB; Q60961; -.
DR ChiTaRS; Laptm4a; mouse.
DR PRO; PR:Q60961; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60961; protein.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; IMP:ParkinsonsUK-UCL.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR004687; LAPTM4/5.
DR InterPro; IPR018396; LAPTM_4A/5.
DR Pfam; PF03821; Mtp; 2.
DR TIGRFAMs; TIGR00799; mtp; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative initiation; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..233
FT /note="Lysosomal-associated transmembrane protein 4A"
FT /id="PRO_0000021783"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q15012"
FT VAR_SEQ 1..89
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_018821"
SQ SEQUENCE 233 AA; 26858 MW; CA409AC77ACE4D6E CRC64;
MVSMTFKRSR SDRFYSTRCC GCFHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV
NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF
VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFV VFIIFKAYLI
NCVWNCYKYI NNRNVPEIAV YPAFETPPQY VLPTYEMAVK IPEKEPPPPY LPA
