ID   LAPM5_BOVIN             Reviewed;         264 AA.
AC   Q2KJA5;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Lysosomal-associated transmembrane protein 5;
DE   AltName: Full=Lysosomal-associated multitransmembrane protein 5;
GN   Name=LAPTM5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a special functional role during embryogenesis and
CC       in adult hematopoietic cells. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to ubiquitin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
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DR   EMBL; BC105438; AAI05439.1; -; mRNA.
DR   RefSeq; NP_001039583.1; NM_001046118.2.
DR   AlphaFoldDB; Q2KJA5; -.
DR   STRING; 9913.ENSBTAP00000055255; -.
DR   PaxDb; Q2KJA5; -.
DR   PRIDE; Q2KJA5; -.
DR   Ensembl; ENSBTAT00000007204; ENSBTAP00000007204; ENSBTAG00000005477.
DR   GeneID; 512361; -.
DR   KEGG; bta:512361; -.
DR   CTD; 7805; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005477; -.
DR   VGNC; VGNC:30788; LAPTM5.
DR   eggNOG; ENOG502RY9P; Eukaryota.
DR   GeneTree; ENSGT00940000153446; -.
DR   HOGENOM; CLU_1065422_0_0_1; -.
DR   InParanoid; Q2KJA5; -.
DR   OMA; VMITFTI; -.
DR   OrthoDB; 1584977at2759; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000005477; Expressed in monocyte and 103 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0140036; F:ubiquitin-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0002357; P:defense response to tumor cell; IEA:Ensembl.
DR   GO; GO:0012502; P:induction of programmed cell death; IEA:Ensembl.
DR   GO; GO:1904093; P:negative regulation of autophagic cell death; IEA:Ensembl.
DR   GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; IEA:Ensembl.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   InterPro; IPR018397; Lysosomal-assoc_TM_prot5.
DR   PANTHER; PTHR12479:SF2; PTHR12479:SF2; 3.
DR   Pfam; PF03821; Mtp; 1.
DR   TIGRFAMs; TIGR00799; mtp; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..264
FT                   /note="Lysosomal-associated transmembrane protein 5"
FT                   /id="PRO_0000249725"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         261
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q61168"
SQ   SEQUENCE   264 AA;  29880 MW;  BF20FD030141C4DA CRC64;
     MAPRAAAIRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KFSKTGYLRI
     AELVSSFLLI TMLFIISLSL LVGVVKNREK YLLPFLSLQI MDFLLCLLTL MGSYIELPAY
     LKFASRSSRR VSPSKVPLMT LQLLDFCLSI LTLCSSYMEV PTYLNFKSMN HMNYLPSQDG
     MTHNQFIKIM IIFSIAFITV LILKVYMFKC VWRCYRLMKC TNSAEERSGS KMLQKVVLPS
     YEEAVSLPYK VPEGGPAPPP YSEV