LAPM5_HUMAN
ID LAPM5_HUMAN Reviewed; 262 AA.
AC Q13571; Q13240; Q14698; Q3KP54;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Lysosomal-associated transmembrane protein 5;
DE AltName: Full=Lysosomal-associated multitransmembrane protein 5;
DE AltName: Full=Retinoic acid-inducible E3 protein;
GN Name=LAPTM5; Synonyms=KIAA0085;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Spleen;
RX PubMed=8661146; DOI=10.1006/geno.1996.0364;
RA Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H.,
RA Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.;
RT "LAPTM5: a novel lysosomal-associated multispanning membrane protein
RT preferentially expressed in hematopoietic cells.";
RL Genomics 35:328-337(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Scott L.M., Collins S.J.;
RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=7788527; DOI=10.1093/dnares/2.1.37;
RA Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S.,
RA Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. III. The
RT coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of
RT cDNA clones from human cell line KG-1.";
RL DNA Res. 2:37-43(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-226.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have a special functional role during embryogenesis and
CC in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}.
CC -!- SUBUNIT: Binds to ubiquitin.
CC -!- INTERACTION:
CC Q13571; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-2865663, EBI-11957045;
CC Q13571; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-2865663, EBI-12003442;
CC Q13571; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-2865663, EBI-12256978;
CC Q13571; P00387: CYB5R3; NbExp=3; IntAct=EBI-2865663, EBI-1046040;
CC Q13571; Q96F81: DISP1; NbExp=3; IntAct=EBI-2865663, EBI-10230179;
CC Q13571; P02724: GYPA; NbExp=3; IntAct=EBI-2865663, EBI-702665;
CC Q13571; P30519: HMOX2; NbExp=3; IntAct=EBI-2865663, EBI-712096;
CC Q13571; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-2865663, EBI-8503746;
CC Q13571; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-2865663, EBI-17272405;
CC Q13571; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-2865663, EBI-10173166;
CC Q13571; Q9H0U6: MRPL18; NbExp=3; IntAct=EBI-2865663, EBI-2560240;
CC Q13571; Q9NS64: RPRM; NbExp=3; IntAct=EBI-2865663, EBI-1052363;
CC Q13571; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-2865663, EBI-10244780;
CC Q13571; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-2865663, EBI-988826;
CC Q13571; P23763-3: VAMP1; NbExp=3; IntAct=EBI-2865663, EBI-12097582;
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:8661146};
CC Multi-pass membrane protein {ECO:0000269|PubMed:8661146}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in adult hematopoietic
CC tissues. High levels in lymphoid and myeloid tissues. Highly expressed
CC in peripheral blood leukocytes, thymus, spleen and lung, followed by
CC placenta, liver and kidney. {ECO:0000269|PubMed:8661146}.
CC -!- INDUCTION: By retinoic acid.
CC -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA07643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U51240; AAB08975.1; -; mRNA.
DR EMBL; U30498; AAA74018.1; -; mRNA.
DR EMBL; D42042; BAA07643.1; ALT_INIT; mRNA.
DR EMBL; BC106896; AAI06897.1; -; mRNA.
DR CCDS; CCDS337.1; -.
DR PIR; G02476; G02476.
DR RefSeq; NP_006753.1; NM_006762.2.
DR AlphaFoldDB; Q13571; -.
DR BioGRID; 113580; 48.
DR IntAct; Q13571; 34.
DR MINT; Q13571; -.
DR STRING; 9606.ENSP00000294507; -.
DR TCDB; 2.A.74.1.4; the 4 tms multidrug endosomal transporter (met) family.
DR iPTMnet; Q13571; -.
DR PhosphoSitePlus; Q13571; -.
DR SwissPalm; Q13571; -.
DR BioMuta; LAPTM5; -.
DR EPD; Q13571; -.
DR jPOST; Q13571; -.
DR MassIVE; Q13571; -.
DR PaxDb; Q13571; -.
DR PeptideAtlas; Q13571; -.
DR PRIDE; Q13571; -.
DR ProteomicsDB; 59574; -.
DR Antibodypedia; 54047; 98 antibodies from 17 providers.
DR DNASU; 7805; -.
DR Ensembl; ENST00000294507.4; ENSP00000294507.3; ENSG00000162511.8.
DR GeneID; 7805; -.
DR KEGG; hsa:7805; -.
DR MANE-Select; ENST00000294507.4; ENSP00000294507.3; NM_006762.3; NP_006753.1.
DR CTD; 7805; -.
DR DisGeNET; 7805; -.
DR GeneCards; LAPTM5; -.
DR HGNC; HGNC:29612; LAPTM5.
DR HPA; ENSG00000162511; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 601476; gene.
DR neXtProt; NX_Q13571; -.
DR OpenTargets; ENSG00000162511; -.
DR PharmGKB; PA134953439; -.
DR VEuPathDB; HostDB:ENSG00000162511; -.
DR eggNOG; ENOG502RY9P; Eukaryota.
DR GeneTree; ENSGT00940000153446; -.
DR HOGENOM; CLU_1065422_0_0_1; -.
DR InParanoid; Q13571; -.
DR OMA; VMITFTI; -.
DR OrthoDB; 1584977at2759; -.
DR PhylomeDB; Q13571; -.
DR TreeFam; TF330843; -.
DR PathwayCommons; Q13571; -.
DR SignaLink; Q13571; -.
DR BioGRID-ORCS; 7805; 11 hits in 1073 CRISPR screens.
DR ChiTaRS; LAPTM5; human.
DR GenomeRNAi; 7805; -.
DR Pharos; Q13571; Tbio.
DR PRO; PR:Q13571; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q13571; protein.
DR Bgee; ENSG00000162511; Expressed in blood and 200 other tissues.
DR ExpressionAtlas; Q13571; baseline and differential.
DR Genevisible; Q13571; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:ARUK-UCL.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0005765; C:lysosomal membrane; IDA:ARUK-UCL.
DR GO; GO:0005764; C:lysosome; IDA:ARUK-UCL.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IMP:ARUK-UCL.
DR GO; GO:0032991; C:protein-containing complex; IDA:ARUK-UCL.
DR GO; GO:0030133; C:transport vesicle; IDA:ARUK-UCL.
DR GO; GO:0140311; F:protein sequestering activity; ISS:ARUK-UCL.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:ARUK-UCL.
DR GO; GO:0140036; F:ubiquitin-dependent protein binding; IMP:ARUK-UCL.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:ARUK-UCL.
DR GO; GO:0002357; P:defense response to tumor cell; IDA:ARUK-UCL.
DR GO; GO:0090160; P:Golgi to lysosome transport; ISS:ARUK-UCL.
DR GO; GO:0012502; P:induction of programmed cell death; IDA:ARUK-UCL.
DR GO; GO:0006886; P:intracellular protein transport; ISS:ARUK-UCL.
DR GO; GO:1904093; P:negative regulation of autophagic cell death; IDA:ARUK-UCL.
DR GO; GO:0050869; P:negative regulation of B cell activation; ISS:ARUK-UCL.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISS:ARUK-UCL.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; ISS:ARUK-UCL.
DR GO; GO:0050868; P:negative regulation of T cell activation; ISS:ARUK-UCL.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:ARUK-UCL.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; ISS:ARUK-UCL.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISS:ARUK-UCL.
DR GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; IDA:ARUK-UCL.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; ISS:ARUK-UCL.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:ARUK-UCL.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:ARUK-UCL.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:ARUK-UCL.
DR GO; GO:2000646; P:positive regulation of receptor catabolic process; ISS:ARUK-UCL.
DR GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; ISS:ARUK-UCL.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; ISS:ARUK-UCL.
DR GO; GO:0006622; P:protein targeting to lysosome; ISS:ARUK-UCL.
DR InterPro; IPR004687; LAPTM4/5.
DR InterPro; IPR018396; LAPTM_4A/5.
DR InterPro; IPR018397; Lysosomal-assoc_TM_prot5.
DR PANTHER; PTHR12479:SF2; PTHR12479:SF2; 3.
DR Pfam; PF03821; Mtp; 1.
DR TIGRFAMs; TIGR00799; mtp; 1.
PE 1: Evidence at protein level;
KW Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..262
FT /note="Lysosomal-associated transmembrane protein 5"
FT /id="PRO_0000084357"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 259
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q61168"
FT VARIANT 226
FT /note="R -> K (in dbSNP:rs35351292)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053653"
FT CONFLICT 249
FT /note="T -> D (in Ref. 2; AAA74018)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 29937 MW; 64A9B3F09C14FCE7 CRC64;
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI
ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY
LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP
HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE
EALSLPSKTP EGGPAPPPYS EV
