LAPM5_MOUSE
ID LAPM5_MOUSE Reviewed; 261 AA.
AC Q61168; Q60923;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Lysosomal-associated transmembrane protein 5;
DE AltName: Full=Lysosomal-associated multitransmembrane protein 5;
DE AltName: Full=Retinoic acid-inducible E3 protein;
GN Name=Laptm5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=Swiss Webster / NIH;
RX PubMed=8661146; DOI=10.1006/geno.1996.0364;
RA Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H.,
RA Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.;
RT "LAPTM5: a novel lysosomal-associated multispanning membrane protein
RT preferentially expressed in hematopoietic cells.";
RL Genomics 35:328-337(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=MDF1;
RX PubMed=8839844;
RA Scott L.M., Mueller L., Collins S.J.;
RT "E3, a hematopoietic-specific transcript directly regulated by the retinoic
RT acid receptor alpha.";
RL Blood 88:2517-2530(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-258, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Mast cell;
RX PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
RA Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA Kawakami T., Salomon A.R.;
RT "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT signaling.";
RL J. Immunol. 179:5864-5876(2007).
CC -!- FUNCTION: May have a special functional role during embryogenesis and
CC in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}.
CC -!- SUBUNIT: Binds to ubiquitin.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:8661146};
CC Multi-pass membrane protein {ECO:0000269|PubMed:8661146}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in adult hematopoietic
CC tissues. High levels in lymphoid and myeloid tissues.
CC {ECO:0000269|PubMed:8661146}.
CC -!- DEVELOPMENTAL STAGE: During embryonic development it is expressed in
CC both hematopoietic and nonhematopoietic tissues.
CC -!- INDUCTION: By retinoic acid. Likely target of the activated retinoic
CC acid receptor alpha.
CC -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC {ECO:0000305}.
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DR EMBL; U51239; AAB08976.1; -; mRNA.
DR EMBL; U29539; AAB48192.1; -; mRNA.
DR EMBL; BC020993; AAH20993.1; -; mRNA.
DR EMBL; BC055057; AAH55057.1; -; mRNA.
DR CCDS; CCDS18712.1; -.
DR RefSeq; NP_034816.1; NM_010686.3.
DR RefSeq; XP_017175490.1; XM_017320001.1.
DR AlphaFoldDB; Q61168; -.
DR BioGRID; 201109; 4.
DR DIP; DIP-37698N; -.
DR IntAct; Q61168; 3.
DR MINT; Q61168; -.
DR STRING; 10090.ENSMUSP00000118415; -.
DR TCDB; 2.A.74.1.2; the 4 tms multidrug endosomal transporter (met) family.
DR iPTMnet; Q61168; -.
DR PhosphoSitePlus; Q61168; -.
DR SwissPalm; Q61168; -.
DR EPD; Q61168; -.
DR MaxQB; Q61168; -.
DR PaxDb; Q61168; -.
DR PRIDE; Q61168; -.
DR ProteomicsDB; 290009; -.
DR Antibodypedia; 54047; 98 antibodies from 17 providers.
DR DNASU; 16792; -.
DR Ensembl; ENSMUST00000151698; ENSMUSP00000118415; ENSMUSG00000028581.
DR GeneID; 16792; -.
DR KEGG; mmu:16792; -.
DR UCSC; uc008uzv.1; mouse.
DR CTD; 7805; -.
DR MGI; MGI:108046; Laptm5.
DR VEuPathDB; HostDB:ENSMUSG00000028581; -.
DR eggNOG; ENOG502RY9P; Eukaryota.
DR GeneTree; ENSGT00940000153446; -.
DR HOGENOM; CLU_1065422_0_0_1; -.
DR InParanoid; Q61168; -.
DR OMA; VMITFTI; -.
DR OrthoDB; 1584977at2759; -.
DR TreeFam; TF330843; -.
DR BioGRID-ORCS; 16792; 0 hits in 58 CRISPR screens.
DR ChiTaRS; Laptm5; mouse.
DR PRO; PR:Q61168; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q61168; protein.
DR Bgee; ENSMUSG00000028581; Expressed in stroma of bone marrow and 252 other tissues.
DR ExpressionAtlas; Q61168; baseline and differential.
DR Genevisible; Q61168; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0005765; C:lysosomal membrane; ISO:MGI.
DR GO; GO:0005764; C:lysosome; IDA:ARUK-UCL.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0030133; C:transport vesicle; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; IPI:ARUK-UCL.
DR GO; GO:0140311; F:protein sequestering activity; IMP:ARUK-UCL.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR GO; GO:0140036; F:ubiquitin-dependent protein binding; ISO:MGI.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0002357; P:defense response to tumor cell; ISO:MGI.
DR GO; GO:0090160; P:Golgi to lysosome transport; IDA:ARUK-UCL.
DR GO; GO:0012502; P:induction of programmed cell death; ISO:MGI.
DR GO; GO:0006886; P:intracellular protein transport; IMP:ARUK-UCL.
DR GO; GO:0046007; P:negative regulation of activated T cell proliferation; IMP:ARUK-UCL.
DR GO; GO:1904093; P:negative regulation of autophagic cell death; ISO:MGI.
DR GO; GO:0050869; P:negative regulation of B cell activation; IMP:ARUK-UCL.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IMP:ARUK-UCL.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IMP:ARUK-UCL.
DR GO; GO:0140646; P:negative regulation of pre-B cell receptor expression; IMP:ARUK-UCL.
DR GO; GO:0050868; P:negative regulation of T cell activation; IMP:ARUK-UCL.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:ARUK-UCL.
DR GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IMP:ARUK-UCL.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IMP:ARUK-UCL.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:ARUK-UCL.
DR GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; ISO:MGI.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IMP:ARUK-UCL.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IMP:ARUK-UCL.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IMP:ARUK-UCL.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IMP:ARUK-UCL.
DR GO; GO:1903052; P:positive regulation of proteolysis involved in protein catabolic process; IMP:ARUK-UCL.
DR GO; GO:2000646; P:positive regulation of receptor catabolic process; IMP:ARUK-UCL.
DR GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; IMP:ARUK-UCL.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IDA:ARUK-UCL.
DR GO; GO:0061462; P:protein localization to lysosome; IMP:ARUK-UCL.
DR GO; GO:0006622; P:protein targeting to lysosome; IDA:ARUK-UCL.
DR InterPro; IPR004687; LAPTM4/5.
DR InterPro; IPR018396; LAPTM_4A/5.
DR InterPro; IPR018397; Lysosomal-assoc_TM_prot5.
DR PANTHER; PTHR12479:SF2; PTHR12479:SF2; 3.
DR Pfam; PF03821; Mtp; 1.
DR TIGRFAMs; TIGR00799; mtp; 1.
PE 1: Evidence at protein level;
KW Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..261
FT /note="Lysosomal-associated transmembrane protein 5"
FT /id="PRO_0000084358"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 242..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 258
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:17947660"
FT CONFLICT 56
FT /note="P -> A (in Ref. 2; AAB48192)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="E -> D (in Ref. 2; AAB48192)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="P -> S (in Ref. 2; AAB48192)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 29602 MW; 70B3FA0AFE6743D1 CRC64;
MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC RFFKMPYLRM
ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI MDFLLCLLTL LGSYIELPAY
LKLARPRPGP SKVPLMTLQL LDFCLSILTL CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH
SQFINMMLIF SVAFITVLIL KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE
ALSLPPKTPE GDPAPPPYSE V
