ID   LAPM5_PONAB             Reviewed;         262 AA.
AC   Q5REZ0;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Lysosomal-associated transmembrane protein 5;
DE   AltName: Full=Lysosomal-associated multitransmembrane protein 5;
GN   Name=LAPTM5;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a special functional role during embryogenesis and
CC       in adult hematopoietic cells. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to ubiquitin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
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DR   EMBL; CR857373; CAH89667.1; -; mRNA.
DR   RefSeq; NP_001124753.1; NM_001131281.2.
DR   AlphaFoldDB; Q5REZ0; -.
DR   STRING; 9601.ENSPPYP00000001875; -.
DR   Ensembl; ENSPPYT00000001934; ENSPPYP00000001875; ENSPPYG00000001624.
DR   GeneID; 100171603; -.
DR   KEGG; pon:100171603; -.
DR   CTD; 7805; -.
DR   eggNOG; ENOG502RY9P; Eukaryota.
DR   GeneTree; ENSGT00940000153446; -.
DR   HOGENOM; CLU_1065422_0_0_1; -.
DR   InParanoid; Q5REZ0; -.
DR   OrthoDB; 1584977at2759; -.
DR   TreeFam; TF330843; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0140036; F:ubiquitin-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0002357; P:defense response to tumor cell; IEA:Ensembl.
DR   GO; GO:0012502; P:induction of programmed cell death; IEA:Ensembl.
DR   GO; GO:1904093; P:negative regulation of autophagic cell death; IEA:Ensembl.
DR   GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; IEA:Ensembl.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   InterPro; IPR018397; Lysosomal-assoc_TM_prot5.
DR   PANTHER; PTHR12479:SF2; PTHR12479:SF2; 3.
DR   Pfam; PF03821; Mtp; 1.
DR   TIGRFAMs; TIGR00799; mtp; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..262
FT                   /note="Lysosomal-associated transmembrane protein 5"
FT                   /id="PRO_0000084359"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         259
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q61168"
SQ   SEQUENCE   262 AA;  29907 MW;  1A230E9315DD0B03 CRC64;
     MDPRLSAVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI
     ADLISSFLLI AMLFIISLSL LIGVVKNREK YLLPFLSLQV MDYLLCLLTL LGSYIELPAY
     LKLASRSRAS PSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP
     HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRFIKCMN SVEEKRNSKM LQKVVLPSYE
     EALSLPSKTP EGGPAPPPYS EV