ID   LAP_BOVIN               Reviewed;          64 AA.
AC   Q28880; Q28202; Q56JV8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Lingual antimicrobial peptide;
DE   Flags: Precursor;
GN   Name=LAP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Tongue epithelium;
RX   PubMed=7886453; DOI=10.1126/science.7886453;
RA   Schonwetter B.S., Stolzenberg E.D., Zasloff M.A.;
RT   "Epithelial antibiotics induced at sites of inflammation.";
RL   Science 267:1645-1648(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymphoid epithelium;
RA   Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.;
RT   "Analysis of sequences obtained from constructed full-length bovine cDNA
RT   libraries.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-64.
RX   PubMed=8613361; DOI=10.1128/iai.64.5.1565-1568.1996;
RA   Russell J.P., Diamond G., Tarver A.P., Scanlin T.F., Bevins C.L.;
RT   "Coordinate induction of two antibiotic genes in tracheal epithelial cells
RT   exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis
RT   factor alpha.";
RL   Infect. Immun. 64:1565-1568(1996).
CC   -!- FUNCTION: Shows a broad spectrum of antibacterial and antifungal
CC       activities. {ECO:0000269|PubMed:7886453}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: In many of the exposed epithelial surfaces
CC       including conjunctivae, bronchi, colon, urinary tract and trachea.
CC       {ECO:0000269|PubMed:7886453}.
CC   -!- DEVELOPMENTAL STAGE: Not found in fetus.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. LAP/TAP subfamily.
CC       {ECO:0000305}.
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DR   EMBL; S76279; AAB33727.1; -; mRNA.
DR   EMBL; AY911374; AAW82137.1; -; mRNA.
DR   EMBL; U48357; AAB05401.1; -; mRNA.
DR   PIR; A56128; A56128.
DR   RefSeq; NP_982259.3; NM_203435.4.
DR   AlphaFoldDB; Q28880; -.
DR   SMR; Q28880; -.
DR   STRING; 9913.ENSBTAP00000046999; -.
DR   PaxDb; Q28880; -.
DR   Ensembl; ENSBTAT00000050266; ENSBTAP00000046999; ENSBTAG00000053889.
DR   GeneID; 403090; -.
DR   KEGG; bta:403090; -.
DR   CTD; 7939; -.
DR   VEuPathDB; HostDB:ENSBTAG00000053889; -.
DR   eggNOG; ENOG502SYUI; Eukaryota.
DR   GeneTree; ENSGT00940000160995; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; Q28880; -.
DR   OMA; QIGTCIL; -.
DR   Reactome; R-BTA-1461957; Beta defensins.
DR   Reactome; R-BTA-1461973; Defensins.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000053889; Expressed in anterior segment of eyeball and 72 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Fungicide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250|UniProtKB:A3RJ36"
FT   PEPTIDE         25..64
FT                   /note="Lingual antimicrobial peptide"
FT                   /id="PRO_0000006965"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   CONFLICT        20
FT                   /note="G -> R (in Ref. 3; AAB05401)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   64 AA;  7041 MW;  BD24CDA3B3912F8F CRC64;
     MRLHHLLLAL LFLVLSAGSG FTQGVRNSQS CRRNKGICVP IRCPGSMRQI GTCLGAQVKC
     CRRK